PDF(Pubmed)
Abstract：
Nanotechnology has demonstrated immense potential in various fields, especially in biomedical field. Among these domains, the development of nanotechnology for diagnosing and treating vascular anomalies has garnered significant attention. Vascular anomalies refer to structural and functional anomalies within the vascular system, which can result in conditions such as vascular malformations and tumors. These anomalies can significantly impact the quality of life of patients and pose significant health concerns. Nanoscale contrast agents have been developed for targeted imaging of blood vessels, enabling more precise identification and characterization of vascular anomalies. These contrast agents can be designed to bind specifically to abnormal blood vessels, providing healthcare professionals with a clearer view of the affected areas. More importantly, nanotechnology also offers promising solutions for targeted therapeutic interventions. Nanoparticles can be engineered to deliver drugs directly to the site of vascular anomalies, maximizing therapeutic effects while minimizing side effects on healthy tissues. Meanwhile, by incorporating functional components into nanoparticles, such as photosensitizers, nanotechnology enables innovative treatment modalities such as photothermal therapy and photodynamic therapy. This review focuses on the applications and potential of nanotechnology in the imaging and therapy of vascular anomalies, as well as discusses the present challenges and future directions.
摘要：
纳米技术在各个领域显示出巨大的潜力，尤其是在生物医学领域。在这些领域中，用于诊断和治疗血管异常的纳米技术的发展引起了极大的关注。血管异常是指血管系统内的结构和功能异常，这可能导致血管畸形和肿瘤等疾病。这些异常可以显著地影响患者的生活质量并且造成显著的健康问题。已经开发了纳米级造影剂用于血管的靶向成像，能够更精确地识别和表征血管异常。这些造影剂可以被设计成特异性结合异常血管，为医疗保健专业人员提供受影响地区的更清晰视图。更重要的是,纳米技术还为有针对性的治疗干预提供了有希望的解决方案。纳米颗粒可以被设计成直接将药物递送到血管异常的部位，最大限度地提高治疗效果，同时最大限度地减少对健康组织的副作用。同时,通过将功能成分结合到纳米粒子中，如光敏剂，纳米技术使创新的治疗方式，如光热疗法和光动力疗法。这篇综述的重点是纳米技术在血管异常的成像和治疗中的应用和潜力。并讨论了当前的挑战和未来的方向。
