PDF(Pubmed)
Abstract：
BACKGROUND: Cervical cancer is the most common malignant tumor among women. It is the main cause of death among women in sub-Saharan African countries. Particularly, the incidence and mortality rates are highest in East Africa. Even though the burden of human papilloma virus-related cervical cancer is high in East Africa, there is no conclusive evidence about the prevalence of human papilloma virus vaccine uptake and its predictors.
OBJECTIVE: To assess the pooled prevalence of human papilloma virus vaccine uptake and its determinants in East Africa.
METHODS: Eligible articles were searched on PubMed, Embase, Scopus, Cochrane Library, Google Scholar, and Google. Those articles incorporating the outcome of interest, both analytical and descriptive study designs, and published or unpublished articles at any time were included. Keywords and Medical Subjects Heading terms or synonyms of human papilloma virus vaccine and Boolean operators were used to retrieve the articles. To assure the quality of articles, Joana Brigg\'s Institute critical appraisal checklist for cross-sectional studies was used. Sensitivity analysis was conducted to assess the heterogeneity among the studies, and a random effect model was used to analyze the pooled effect size.
RESULTS: A total of 29 articles were included, and the pooled prevalence of HPV vaccine uptake in East Africa was 35% (95% CI: 26-45%). Good knowledge (OR = 1.6, 95%CI; 1.43-1.8), positive attitude (OR = 2.54, 95% CI; 2.13-3.03), ever heard about HPV vaccine (OR = 1.41, 95% CI; 1.03-1.94), mother educational status above college (OR = 1.84, 95%CI; 1.03-3.31), middle wealth index (OR = 1.33, 95%CI; 1.04-1.7), ≥ 9 family size (OR = 0.76, 95%CI; 0.68-0.98), availability of promotion (OR = 2.53, 95%CI: 1.51-4.26), availability of adequate vaccine (OR = 4.84, 95%CI; 2.9-8.08), outreach vaccination practice (OR = 1.47, 95%CI; 1.02-2.12) and family support (OR = 4.3, 95% CI; 2.98-6.21) were the significant factors for the uptake of human papilloma virus vaccine.
CONCLUSIONS: As compared to the global strategic plan, the pooled prevalence of HPV vaccine uptake in east Africa was low. The uptake of the HPV vaccine was higher among adolescents than youths. Knowledge about the HPV vaccine, attitude towards the HPV vaccine, ever hearing about the HPV vaccine, residence, mother\'s educational status, mother\'s occupational status, wealth index, and family size were the significant determinants of HPV vaccine uptake. Therefore, we recommend focusing on awareness creation and behavioral change to expand the uptake of vaccines in East Africa.
OBJECTIVE: To assess the pooled prevalence of human papilloma virus vaccine uptake and its determinants in East Africa.
METHODS: Eligible articles were searched on PubMed, Embase, Scopus, Cochrane Library, Google Scholar, and Google. Those articles incorporating the outcome of interest, both analytical and descriptive study designs, and published or unpublished articles at any time were included. Keywords and Medical Subjects Heading terms or synonyms of human papilloma virus vaccine and Boolean operators were used to retrieve the articles. To assure the quality of articles, Joana Brigg\'s Institute critical appraisal checklist for cross-sectional studies was used. Sensitivity analysis was conducted to assess the heterogeneity among the studies, and a random effect model was used to analyze the pooled effect size.
RESULTS: A total of 29 articles were included, and the pooled prevalence of HPV vaccine uptake in East Africa was 35% (95% CI: 26-45%). Good knowledge (OR = 1.6, 95%CI; 1.43-1.8), positive attitude (OR = 2.54, 95% CI; 2.13-3.03), ever heard about HPV vaccine (OR = 1.41, 95% CI; 1.03-1.94), mother educational status above college (OR = 1.84, 95%CI; 1.03-3.31), middle wealth index (OR = 1.33, 95%CI; 1.04-1.7), ≥ 9 family size (OR = 0.76, 95%CI; 0.68-0.98), availability of promotion (OR = 2.53, 95%CI: 1.51-4.26), availability of adequate vaccine (OR = 4.84, 95%CI; 2.9-8.08), outreach vaccination practice (OR = 1.47, 95%CI; 1.02-2.12) and family support (OR = 4.3, 95% CI; 2.98-6.21) were the significant factors for the uptake of human papilloma virus vaccine.
CONCLUSIONS: As compared to the global strategic plan, the pooled prevalence of HPV vaccine uptake in east Africa was low. The uptake of the HPV vaccine was higher among adolescents than youths. Knowledge about the HPV vaccine, attitude towards the HPV vaccine, ever hearing about the HPV vaccine, residence, mother\'s educational status, mother\'s occupational status, wealth index, and family size were the significant determinants of HPV vaccine uptake. Therefore, we recommend focusing on awareness creation and behavioral change to expand the uptake of vaccines in East Africa.
摘要：
背景：宫颈癌是女性中最常见的恶性肿瘤。它是撒哈拉以南非洲国家妇女死亡的主要原因。特别是,发病率和死亡率在东非最高。尽管人类乳头状瘤病毒相关宫颈癌的负担在东非很高，目前尚无关于人乳头瘤病毒疫苗摄取率及其预测因素的确凿证据。
目的：评估东非人类乳头瘤病毒疫苗摄取及其决定因素的合并流行率。
方法：在PubMed上搜索了符合条件的文章，Embase,Scopus,科克伦图书馆,谷歌学者，和Google。那些包含感兴趣结果的文章，分析性和描述性研究设计，并包括在任何时候发表或未发表的文章。关键词和医学主题使用人乳头瘤病毒疫苗的标题术语或同义词和布尔运算符检索文章。为了保证物品的质量，使用JoanaBrigg研究所的横断面研究关键评估清单。进行敏感性分析以评估研究之间的异质性，并使用随机效应模型分析合并效应大小。
结果：共纳入29篇文章，在东非,HPV疫苗摄取的合并流行率为35%(95%CI:26-45%).良好的知识（OR=1.6，95CI；1.43-1.8），积极态度(OR=2.54，95%CI；2.13-3.03)，听说过HPV疫苗（OR=1.41，95%CI；1.03-1.94），母亲的学历在大学以上（OR=1.84，95CI；1.03-3.31），中等财富指数(OR=1.33，95CI；1.04-1.7)，≥9个家庭（OR=0.76，95CI；0.68-0.98），晋升的可用性(OR=2.53，95CI：1.51-4.26)，充足疫苗的可用性(OR=4.84，95CI；2.9-8.08)，外展疫苗接种实践（OR=1.47，95CI；1.02-2.12）和家庭支持（OR=4.3，95％CI；2.98-6.21）是吸收人乳头瘤病毒疫苗的重要因素。
结论：与全球战略计划相比，在东非,HPV疫苗摄取的汇总患病率较低.青少年对HPV疫苗的摄取高于青少年。关于HPV疫苗的知识，对HPV疫苗的态度，听说过HPV疫苗，residence,母亲的教育状况，母亲的职业状况，财富指数，和家庭规模是HPV疫苗摄取的重要决定因素。因此,我们建议将重点放在提高认识和行为改变上,以扩大东非疫苗的使用.
目的：评估东非人类乳头瘤病毒疫苗摄取及其决定因素的合并流行率。
方法：在PubMed上搜索了符合条件的文章，Embase,Scopus,科克伦图书馆,谷歌学者，和Google。那些包含感兴趣结果的文章，分析性和描述性研究设计，并包括在任何时候发表或未发表的文章。关键词和医学主题使用人乳头瘤病毒疫苗的标题术语或同义词和布尔运算符检索文章。为了保证物品的质量，使用JoanaBrigg研究所的横断面研究关键评估清单。进行敏感性分析以评估研究之间的异质性，并使用随机效应模型分析合并效应大小。
结果：共纳入29篇文章，在东非,HPV疫苗摄取的合并流行率为35%(95%CI:26-45%).良好的知识（OR=1.6，95CI；1.43-1.8），积极态度(OR=2.54，95%CI；2.13-3.03)，听说过HPV疫苗（OR=1.41，95%CI；1.03-1.94），母亲的学历在大学以上（OR=1.84，95CI；1.03-3.31），中等财富指数(OR=1.33，95CI；1.04-1.7)，≥9个家庭（OR=0.76，95CI；0.68-0.98），晋升的可用性(OR=2.53，95CI：1.51-4.26)，充足疫苗的可用性(OR=4.84，95CI；2.9-8.08)，外展疫苗接种实践（OR=1.47，95CI；1.02-2.12）和家庭支持（OR=4.3，95％CI；2.98-6.21）是吸收人乳头瘤病毒疫苗的重要因素。
结论：与全球战略计划相比，在东非,HPV疫苗摄取的汇总患病率较低.青少年对HPV疫苗的摄取高于青少年。关于HPV疫苗的知识，对HPV疫苗的态度，听说过HPV疫苗，residence,母亲的教育状况，母亲的职业状况，财富指数，和家庭规模是HPV疫苗摄取的重要决定因素。因此,我们建议将重点放在提高认识和行为改变上,以扩大东非疫苗的使用.
