PDF(Pubmed)
Abstract：
BACKGROUND: Inflammatory bowel diseases, consisting of Crohn\'s disease and ulcerative colitis, are chronic bowel relapsing inflammatory disorders. Inflammatory bowel diseases begin rarely in infants. Approximately 25% of patients with inflammatory bowel diseases present before the age of 20 years. Very early-onset inflammatory bowel disease occurs before the age of 6 years; infantile inflammatory bowel diseases occurs before the age of 2 years, and is extremely rare in infants under 1 year of age.
METHODS: Herein, we report a case series of 7-month-, 11-month-, and 12-month-old Syrian infants that presented with diarrhea, hematochezia, and pale appearance and were finally diagnosed with infantile inflammatory bowel disease and treated.
CONCLUSIONS: Early diagnosis and ruling out infantile inflammatory bowel diseases despite its rarity are recommended. Over and above that, new drugs such as vedolizumab, golimumab, and less invasive treatment methods should also be taken into consideration for better response and adequate remission with improved quality of life.
METHODS: Herein, we report a case series of 7-month-, 11-month-, and 12-month-old Syrian infants that presented with diarrhea, hematochezia, and pale appearance and were finally diagnosed with infantile inflammatory bowel disease and treated.
CONCLUSIONS: Early diagnosis and ruling out infantile inflammatory bowel diseases despite its rarity are recommended. Over and above that, new drugs such as vedolizumab, golimumab, and less invasive treatment methods should also be taken into consideration for better response and adequate remission with improved quality of life.
摘要：
背景：炎症性肠病，包括克罗恩病和溃疡性结肠炎，是慢性肠复发性炎症性疾病。炎症性肠病很少在婴儿中开始。大约25％的炎症性肠病患者在20岁之前出现。非常早发性炎症性肠病发生在6岁之前;婴儿炎症性肠病发生在2岁之前，在1岁以下的婴儿中极为罕见。
方法：这里，我们报告了一系列7个月的病例-，11个月-，和12个月大的叙利亚婴儿出现腹泻，便血,和苍白的外观，最后被诊断为婴儿炎症性肠病和治疗。
结论：建议早期诊断和排除婴儿炎症性肠病，尽管其罕见。除此之外，新药如维多珠单抗，戈利木单抗,和侵入性较小的治疗方法也应考虑到更好的反应和足够的缓解，提高生活质量。
方法：这里，我们报告了一系列7个月的病例-，11个月-，和12个月大的叙利亚婴儿出现腹泻，便血,和苍白的外观，最后被诊断为婴儿炎症性肠病和治疗。
结论：建议早期诊断和排除婴儿炎症性肠病，尽管其罕见。除此之外，新药如维多珠单抗，戈利木单抗,和侵入性较小的治疗方法也应考虑到更好的反应和足够的缓解，提高生活质量。
