Abstract：
The sequential change from totipotency to multipotency occurs during early mammalian embryo development. However, due to the lack of cellular models to recapitulate the distinct potency of stem cells at each stage, their molecular and cellular characteristics remain ambiguous. The establishment of isogenic naïve and primed pluripotent stem cells to represent the pluripotency in the inner cell mass of the pre-implantation blastocyst and in the epiblast from the post-implantation embryo allows the understanding of the distinctive characteristics of two different states of pluripotent stem cells. This review discusses the prominent disparities between naïve and primed pluripotency, including signaling pathways, metabolism, and epigenetic status, ultimately facilitating a comprehensive understanding of their significance during early mammalian embryonic development.
摘要：
从全能性到多能性的顺序变化发生在早期哺乳动物胚胎发育期间。然而,由于缺乏细胞模型来概括干细胞在每个阶段的独特潜能，它们的分子和细胞特征仍然模棱两可。建立等基因的原始和引发的多能干细胞以代表植入前胚泡的内细胞团和来自植入后胚胎的上胚层中的多能性，可以理解多能干细胞的两种不同状态的独特特征。这篇综述讨论了幼稚多能性和初步多能性之间的显著差异，包括信号通路，新陈代谢，和表观遗传状态，最终有助于全面了解它们在早期哺乳动物胚胎发育过程中的意义。
