PDF(Pubmed)
Abstract：
Egg weight (EW) and age at first egg (AFE) are economically important traits in breeder chicken production. The genetic basis of these traits, however, is far from understood, especially for broiler breeders. In this study, genetic parameter estimation, genome-wide association analysis, meta-analysis, and selective sweep analysis were carried out to identify genetic loci associated with EW and AFE in 6,842 broiler breeders. The study found that the heritability of EW ranged from 0.42 to 0.44, while the heritability of AFE was estimated at 0.33 in the maternal line. Meta-analysis and selective sweep analysis identified two colocalized regions on GGA4 that significantly influenced EW at 32 wk (EW32W) and at 43 wk (EW43W) with both paternal and maternal lines. The genes AR, YIPF6, and STARD8 were located within the significant region (GGA4: 366.86-575.50 kb), potentially affecting EW through the regulation of follicle development, cell proliferation, and lipid transfer etc. The promising genes LCORL and NCAPG were positioned within the significant region (GGA4:75.35-75.42 Mb), potentially influencing EW through pleiotropic effects on growth and development. Additionally, 3 significant regions were associated with AFE on chromosomes GGA7, GGA19, and GGA27. All of these factors affected the AFE by influencing ovarian development. In our study, the genomic information from both paternal and maternal lines was used to identify genetic regions associated with EW and AFE. Two genomic regions and eight genes were identified as the most likely candidates affecting EW and AFE. These findings contribute to a better understanding of the genetic basis of egg production traits in broiler breeders and provide new insights into future technology development.
摘要：
蛋重（EW）和初蛋年龄（AFE）是种鸡生产中的重要经济性状。这些性状的遗传基础，然而,远未被理解,尤其是对肉鸡饲养员。在这项研究中,遗传参数估计，全基因组关联分析，荟萃分析，并进行了选择性扫描分析，以鉴定与6,842只肉鸡饲养员的EW和AFE相关的遗传位点。研究发现，EW的遗传力范围为0.42至0.44，而在母系中，AFE的遗传力估计为0.33。荟萃分析和选择性扫描分析确定了GGA4上的两个共同定位区域，它们在父系和母系的32周（EW32W）和43周（EW43W）显着影响EW。AR基因，YIPF6和STARD8位于重要区域内（GGA4：366.86-575.50kb），通过调节卵泡发育可能影响EW，细胞增殖，和脂质转移等.有希望的基因LCORL和NCAPG位于显著区域内（GGA4：75.35-75.42Mb），通过对生长发育的多效性影响潜在的EW。此外,3个显著区域与染色体GGA7、GGA19和GGA27上的AFE相关。所有这些因素都通过影响卵巢发育来影响AFE。在我们的研究中,来自父系和母系的基因组信息用于鉴定与EW和AFE相关的遗传区域.两个基因组区域和八个基因被鉴定为最可能影响EW和AFE的候选物。这些发现有助于更好地了解肉鸡种鸡产蛋性状的遗传基础，并为未来的技术发展提供新的见解。
