Abstract：
Vaccine strains Yersinia pestis EV NIIEG at a dose of 103 CFU and Francisella tularensis 15 NIIEG at a dose of 102 CFU induced changes in the concentration of cyclic nucleotides in the thymus and spleen of white mice. Antigen-induced changes in the cAMP/cGMP ratio in immunocompetent organs had a phase or oscillatory character, which seems to be related to the regulation of postvaccination immunoreactivity in the body. Synthetic organoselenium compound 974zh stimulated an increase in the amplitude of cAMP/cGMP oscillations, indicating its stimulating effect on the immunogenic properties of vaccine strains at doses an order of magnitude below the standard doses.
摘要：
103CFU剂量的鼠疫耶尔森氏菌EVNIIEG和102CFU剂量的土伦弗朗西斯菌15NIIEG疫苗株诱导白色小鼠胸腺和脾脏中环核苷酸浓度的变化。抗原诱导的免疫功能器官中cAMP/cGMP比率的变化具有相位或振荡特性，这似乎与体内疫苗接种后免疫反应性的调节有关。合成有机硒化合物974zh刺激了cAMP/cGMP振荡幅度的增加，表明其在低于标准剂量一个数量级的剂量下对疫苗株的免疫原性的刺激作用。
