%0 Journal Article
%T Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation.
%A Dubrovina VI
%A Yur'eva OV
%A Pyatidesyatnikova AB
%A Starovoitova TP
%A Balakhonov SV
%J Bull Exp Biol Med
%V 176
%N 4
%D 2024 Feb 16
%M 38492103
%F 0.737
%R 10.1007/s10517-024-06049-4
%X Vaccine strains Yersinia pestis EV NIIEG at a dose of 103 CFU and Francisella tularensis 15 NIIEG at a dose of 102 CFU induced changes in the concentration of cyclic nucleotides in the thymus and spleen of white mice. Antigen-induced changes in the cAMP/cGMP ratio in immunocompetent organs had a phase or oscillatory character, which seems to be related to the regulation of postvaccination immunoreactivity in the body. Synthetic organoselenium compound 974zh stimulated an increase in the amplitude of cAMP/cGMP oscillations, indicating its stimulating effect on the immunogenic properties of vaccine strains at doses an order of magnitude below the standard doses.