PDF(Pubmed)
Abstract：
BACKGROUND: California is home to the largest population of Armenians in the United States. The historical categorization of Armenians as \'White\' or \'Some Other Race\' in population databases has likely masked cancer incidence patterns in this population. This is the first study considering cancer incidence among Armenians in California.
METHODS: We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with cancer diagnosed during 1988-2019. We calculated proportional incidence ratios (PIR) among Armenians compared with non-Hispanic Whites (NHWs). As an exploratory analysis, we calculated incidence rate ratios (IRR) during 2006-2015 using Armenian population denominators from the American Community Survey (ACS). We selected PIR as our primary method given uncertainty regarding the use of ACS population estimates for rate calculations.
RESULTS: There were 27,212 cancer diagnoses among Armenians in California, 13,754 among males and 13,458 among females. Armenian males had notably higher proportions of stomach (PIR = 2.39), thyroid (PIR = 1.45), and tobacco-related cancers including bladder (PIR = 1.53), colorectal (PIR = 1.29), and lung (PIR = 1.16) cancers. Higher proportional incidence of cancers including stomach (PIR = 3.24), thyroid (PIR = 1.47), and colorectal (PIR = 1.29) were observed among Armenian females. Exploratory IRR analyses showed higher stomach (IRR = 1.78), bladder (IRR = 1.13), and colorectal (IRR = 1.12) cancers among Armenian males and higher stomach (IRR = 2.54) cancer among Armenian females.
CONCLUSIONS: We observed higher stomach, colorectal and thyroid cancer incidence among males and females, and tobacco-related cancers among males. Further research is needed to refine Armenian population estimates and understand and address risk factors associated with specific cancers among Armenians in California.
METHODS: We used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with cancer diagnosed during 1988-2019. We calculated proportional incidence ratios (PIR) among Armenians compared with non-Hispanic Whites (NHWs). As an exploratory analysis, we calculated incidence rate ratios (IRR) during 2006-2015 using Armenian population denominators from the American Community Survey (ACS). We selected PIR as our primary method given uncertainty regarding the use of ACS population estimates for rate calculations.
RESULTS: There were 27,212 cancer diagnoses among Armenians in California, 13,754 among males and 13,458 among females. Armenian males had notably higher proportions of stomach (PIR = 2.39), thyroid (PIR = 1.45), and tobacco-related cancers including bladder (PIR = 1.53), colorectal (PIR = 1.29), and lung (PIR = 1.16) cancers. Higher proportional incidence of cancers including stomach (PIR = 3.24), thyroid (PIR = 1.47), and colorectal (PIR = 1.29) were observed among Armenian females. Exploratory IRR analyses showed higher stomach (IRR = 1.78), bladder (IRR = 1.13), and colorectal (IRR = 1.12) cancers among Armenian males and higher stomach (IRR = 2.54) cancer among Armenian females.
CONCLUSIONS: We observed higher stomach, colorectal and thyroid cancer incidence among males and females, and tobacco-related cancers among males. Further research is needed to refine Armenian population estimates and understand and address risk factors associated with specific cancers among Armenians in California.
摘要：
背景：加利福尼亚州是美国亚美尼亚人人口最多的地方。人口数据库中亚美尼亚人的历史分类为“白人”或“其他种族”可能掩盖了该人群的癌症发病率模式。这是第一项考虑加利福尼亚州亚美尼亚人癌症发病率的研究。
方法：我们使用加利福尼亚癌症登记处的亚美尼亚姓氏列表和出生地信息来识别1988-2019年期间诊断为癌症的亚美尼亚人。我们计算了亚美尼亚人与非西班牙裔白人（NHW）的比例发病率（PIR）。作为探索性分析，我们使用来自美国社区调查(ACS)的亚美尼亚人口分母计算了2006-2015年期间的发病率比率(IRR).考虑到使用ACS人口估计进行比率计算的不确定性，我们选择PIR作为主要方法。
结果：在加利福尼亚州的亚美尼亚人中有27,212例癌症诊断，男性为13,754，女性为13,458。亚美尼亚男性的胃比例明显较高（PIR=2.39），甲状腺（PIR=1.45），和烟草相关的癌症，包括膀胱癌（PIR=1.53），结直肠（PIR=1.29），和肺癌（PIR=1.16）。包括胃癌在内的癌症比例较高（PIR=3.24），甲状腺（PIR=1.47），在亚美尼亚女性中观察到结直肠（PIR=1.29）。探索性IRR分析显示胃部较高（IRR=1.78），膀胱（IRR=1.13），亚美尼亚男性的结直肠癌（IRR=1.12）和亚美尼亚女性的高胃癌（IRR=2.54）。
结论：我们观察到胃较高，男性和女性的结直肠癌和甲状腺癌发病率，和男性的烟草相关癌症。需要进一步的研究来完善亚美尼亚人口估计，并了解和解决与加利福尼亚州亚美尼亚人中特定癌症相关的风险因素。
方法：我们使用加利福尼亚癌症登记处的亚美尼亚姓氏列表和出生地信息来识别1988-2019年期间诊断为癌症的亚美尼亚人。我们计算了亚美尼亚人与非西班牙裔白人（NHW）的比例发病率（PIR）。作为探索性分析，我们使用来自美国社区调查(ACS)的亚美尼亚人口分母计算了2006-2015年期间的发病率比率(IRR).考虑到使用ACS人口估计进行比率计算的不确定性，我们选择PIR作为主要方法。
结果：在加利福尼亚州的亚美尼亚人中有27,212例癌症诊断，男性为13,754，女性为13,458。亚美尼亚男性的胃比例明显较高（PIR=2.39），甲状腺（PIR=1.45），和烟草相关的癌症，包括膀胱癌（PIR=1.53），结直肠（PIR=1.29），和肺癌（PIR=1.16）。包括胃癌在内的癌症比例较高（PIR=3.24），甲状腺（PIR=1.47），在亚美尼亚女性中观察到结直肠（PIR=1.29）。探索性IRR分析显示胃部较高（IRR=1.78），膀胱（IRR=1.13），亚美尼亚男性的结直肠癌（IRR=1.12）和亚美尼亚女性的高胃癌（IRR=2.54）。
结论：我们观察到胃较高，男性和女性的结直肠癌和甲状腺癌发病率，和男性的烟草相关癌症。需要进一步的研究来完善亚美尼亚人口估计，并了解和解决与加利福尼亚州亚美尼亚人中特定癌症相关的风险因素。
