Abstract：
Porcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE\'s antiviral attributes. This encompasses a dual-phase analysis of CAPE\'s interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication. Varied dosages of CAPE were subjected to empirical testing in animal models to quantify its efficacy in combating PRRSV infections. The findings reveal a pronounced antiviral potency, notably in prophylactic scenarios. As a predominant component of propolis, CAPE stands out as a promising candidate for clinical suppression, showing exceptional effectiveness in pre-exposure prophylaxis regimes. This highlights the potential of CAPE in spearheading cutting-edge strategies for the management of future PRRSV outbreaks.
摘要：
猪繁殖与呼吸综合征（PRRS）在养猪业中提出了强大的病毒挑战。面对现有兽药和疫苗的限制，本研究以咖啡酸苯乙酯(CAPE)作为猪繁殖与呼吸综合征病毒(PRRSV)的前瞻性临床抑制剂为中心.该研究采用综合方法来评估CAPE的抗病毒属性。这包括CAPE与PRRSV相互作用的双相分析，在体外和体内，并检查其对病毒复制的影响。在动物模型中对不同剂量的CAPE进行经验测试,以量化其对抗PRRSV感染的功效。这些发现揭示了明显的抗病毒效力，特别是在预防情况下。作为蜂胶的主要成分，CAPE是临床抑制的有希望的候选者，在暴露前预防制度中表现出非凡的有效性。这凸显了CAPE在引领管理未来PRRSV爆发的前沿战略方面的潜力。
