Abstract：
Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia. Phosphorylated tau (p-tau) is a hallmark biological manifestation of Alzheimer disease (AD). We investigated associations between MBI and tau accumulation in early-stage AD cortical regions. In 442 Alzheimer\'s Disease Neuroimaging Initiative participants with normal cognition or mild cognitive impairment, MBI status was determined alongside corresponding p-tau and Aβ. Two meta-regions of interest were generated to represent Braak I and III neuropathological stages. Multivariable linear regression modelled the association between MBI as independent variable and tau tracer uptake as dependent variable. Among Aβ positive individuals, MBI was associated with tau uptake in Braak I (β=0.45(0.15), p<.01) and Braak III (β=0.24(0.07), p<.01) regions. In Aβ negative individuals, MBI was not associated with tau in the Braak I region (p=0.11) with a negative association in Braak III (p=.01). These findings suggest MBI may be a sequela of neurodegeneration, and can be implemented as a cost-effective framework to help improve screening efficiency for AD.
摘要：
轻度行为损害（MBI）利用晚年出现和持续的神经精神症状（NPS）来确定痴呆的高危人群。磷酸化tau(p-tau)是阿尔茨海默病(AD)的标志生物学表现。我们调查了MBI和早期AD皮层区域tau积累之间的关联。在442名认知正常或轻度认知障碍的阿尔茨海默病神经影像学研究参与者中，MBI状态与相应的p-tau和Aβ一起确定。产生两个感兴趣的元区域以代表BraakI和III神经病理学阶段。多变量线性回归模拟了作为自变量的MBI与作为因变量的tau示踪剂摄取之间的关联。在Aβ阳性个体中，MBI与BraakI的tau摄取相关（β=0.45（0.15），p<.01)和BraakIII(β=0.24(0.07)，p<.01)区域。在Aβ阴性个体中，MBI与BraakI区的tau无关（p=0.11），而BraakIII中则呈负相关（p=0.01）。这些发现表明MBI可能是神经变性的后遗症，并且可以作为具有成本效益的框架来实施，以帮助提高AD的筛查效率。
