Abstract：
OBJECTIVE: Synovial sarcoma (SS) is a relatively rare type of soft-tissue sarcoma that is commonly treated with surgery, radiation, chemotherapy, and palliative care. Stereotactic radiosurgery (SRS) is an emerging approach that shows promise in treating CNS conditions, but it has not been studied for SS. The authors present a systematic review that explores the effectiveness of different treatments, with a focus on SRS, for managing spinal SS.
METHODS: A systematic PubMed search was conducted that covered studies from 1964 to 2022, yielding 70 relevant studies. Inclusion criteria encompassed primary and metastatic spinal SS, various treatment modalities, patient age 17 years or older, English-language studies, retrospective series, and case reports. Based on these criteria, 26 studies were included in this review and 44 were excluded.
RESULTS: Of the included studies, 15 patients from 9 studies were treated with surgical intervention followed by both conventional radiotherapy (RT) and chemotherapy, 10 patients from 10 studies were treated with surgery followed by RT, 5 studies comprising 8 patients were exclusively treated with surgery, 5 cases in 3 studies were treated with surgery plus concomitant chemotherapy, 4 patients in 2 studies were treated with SRS, and only 1 study reported treatment without surgery and with chemotherapy and RT. The median progression-free survival and overall survival periods observed in the SRS-treated patients were 37 months and 60 months, respectively, which were higher than those of any other treatment method or combination used.
CONCLUSIONS: The authors\' study offers a thorough review of spinal SS treatments. They are hopeful that this will aid clinicians in informed decision-making for better patient outcomes.
METHODS: A systematic PubMed search was conducted that covered studies from 1964 to 2022, yielding 70 relevant studies. Inclusion criteria encompassed primary and metastatic spinal SS, various treatment modalities, patient age 17 years or older, English-language studies, retrospective series, and case reports. Based on these criteria, 26 studies were included in this review and 44 were excluded.
RESULTS: Of the included studies, 15 patients from 9 studies were treated with surgical intervention followed by both conventional radiotherapy (RT) and chemotherapy, 10 patients from 10 studies were treated with surgery followed by RT, 5 studies comprising 8 patients were exclusively treated with surgery, 5 cases in 3 studies were treated with surgery plus concomitant chemotherapy, 4 patients in 2 studies were treated with SRS, and only 1 study reported treatment without surgery and with chemotherapy and RT. The median progression-free survival and overall survival periods observed in the SRS-treated patients were 37 months and 60 months, respectively, which were higher than those of any other treatment method or combination used.
CONCLUSIONS: The authors\' study offers a thorough review of spinal SS treatments. They are hopeful that this will aid clinicians in informed decision-making for better patient outcomes.
摘要：
目的：滑膜肉瘤（SS）是一种相对罕见的软组织肉瘤，通常通过手术治疗，辐射,化疗,和姑息治疗。立体定向放射外科（SRS）是一种新兴的方法，在治疗中枢神经系统疾病中显示出希望，但尚未对SS进行研究。作者提出了一个系统的综述，探讨了不同治疗方法的有效性，专注于SRS，用于管理脊髓SS。
方法：进行了系统的PubMed搜索，涵盖了1964年至2022年的研究，产生了70项相关研究。纳入标准包括原发性和转移性脊柱SS，各种治疗方式，患者年龄17岁或以上，英语语言研究,回顾性系列，和病例报告。基于这些标准,26项研究被纳入本综述，44项被排除。
结果：在纳入的研究中，来自9项研究的15例患者接受手术干预，然后进行常规放疗（RT）和化疗，来自10项研究的10例患者接受了手术治疗，然后接受RT治疗，5项研究包括8例患者，仅接受手术治疗，3项研究中有5例采用手术加联合化疗治疗，2项研究中的4例患者接受了SRS治疗，只有1项研究报告了没有手术，化疗和RT的治疗。在接受SRS治疗的患者中观察到的中位无进展生存期和总生存期分别为37个月和60个月。分别,高于任何其他治疗方法或组合使用的方法。
结论：作者的研究提供了对脊柱SS治疗的全面回顾。他们希望这将有助于临床医生做出明智的决策，以获得更好的患者结果。
方法：进行了系统的PubMed搜索，涵盖了1964年至2022年的研究，产生了70项相关研究。纳入标准包括原发性和转移性脊柱SS，各种治疗方式，患者年龄17岁或以上，英语语言研究,回顾性系列，和病例报告。基于这些标准,26项研究被纳入本综述，44项被排除。
结果：在纳入的研究中，来自9项研究的15例患者接受手术干预，然后进行常规放疗（RT）和化疗，来自10项研究的10例患者接受了手术治疗，然后接受RT治疗，5项研究包括8例患者，仅接受手术治疗，3项研究中有5例采用手术加联合化疗治疗，2项研究中的4例患者接受了SRS治疗，只有1项研究报告了没有手术，化疗和RT的治疗。在接受SRS治疗的患者中观察到的中位无进展生存期和总生存期分别为37个月和60个月。分别,高于任何其他治疗方法或组合使用的方法。
结论：作者的研究提供了对脊柱SS治疗的全面回顾。他们希望这将有助于临床医生做出明智的决策，以获得更好的患者结果。
