关键词: Alzheimer’s disease cognitive function dementia diabetes mild cognitive impairment older adults racial/ethnic disparities wealth

Mesh : Humans United States / epidemiology Adult Middle Aged Aged Ethnicity Diabetes Mellitus, Type 2 / epidemiology Cognition Cognitive Dysfunction / epidemiology psychology Alzheimer Disease / epidemiology

来  源:   DOI:10.3233/JAD-231107

Abstract:
UNASSIGNED: The prevalence of type 2 diabetes is increasing with the burden disproportionately falling on older adults and racial/ethnic minorities. Older adults with diabetes show greater cognitive decline and there are disparities in cognitive function by race/ethnicity that can be explained by social determinants such as wealth.
UNASSIGNED: To understand whether there is a differential relationship between wealth and cognitive function by race/ethnicity among older U.S. adults with diabetes.
UNASSIGNED: Data on 9,006 adults aged 50+ with diabetes from the Health and Retirement Study (2006-2016) were analyzed. The primary outcome, cognitive function, was a score ranging from range 0-27 categorized as: normal [12-27], mild cognitive impairment (MCI) [7-11], and dementia including Alzheimer\'s disease [0-6]. Three modeled outcomes were: 1) normal versus MCI, 2) normal versus dementia, 3) MCI versus dementia. Wealth was log transformed and used as continuous and binary (≥median, UNASSIGNED: In adjusted models, greater wealth was significantly associated with lower odds of MCI and dementia for all groups. Similarly, having wealth less than the sample median was associated with higher odds of MCI and dementia compared to wealth≥sample median.
UNASSIGNED: Increased wealth was significantly protective against MCI and dementia for all ethnic groups. Wealth less than the sample median was associated with greater odds of dementia for NHB and NHW.
摘要:
2型糖尿病的患病率正在增加,负担不成比例地落在老年人和种族/少数民族身上。患有糖尿病的老年人表现出更大的认知能力下降,并且种族/种族之间的认知功能存在差异,这可以通过财富等社会决定因素来解释。
了解在美国老年糖尿病患者中,财富与认知功能之间是否存在种族/种族之间的差异关系。
分析了健康与退休研究(2006-2016)中9,006名50岁以上患有糖尿病的成年人的数据。主要结果,认知功能,得分范围为0-27,分类为:正常[12-27],轻度认知障碍(MCI)[7-11],和痴呆症,包括阿尔茨海默病[0-6]。三个建模结果是:1)正常与MCI,2)正常与痴呆,3)MCI与痴呆。财富被对数变换,并被用作连续和二元(≥中位数,<中位数)。使用Logistic广义估计方程模型来检验财富与认知功能之间的关系,并根据种族/种族对模型进行分层。模型根据人口统计进行了调整,生活方式,功能限制,和合并症。
在调整后的模型中,在所有组,财富增加与MCI和痴呆发生几率降低显著相关.同样,财富低于样本中位数与财富≥样本中位数相比,MCI和痴呆的几率较高.
财富的增加对所有种族群体的MCI和痴呆具有显著的保护作用。财富低于样本中位数与NHB和NHW患痴呆症的几率更高相关。
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