PDF(Pubmed)
Abstract：
The pelvic organs (bladder, rectum, and sex organs) have been represented for a century as receiving autonomic innervation from two pathways - lumbar sympathetic and sacral parasympathetic - by way of a shared relay, the pelvic ganglion, conceived as an assemblage of sympathetic and parasympathetic neurons. Using single-cell RNA sequencing, we find that the mouse pelvic ganglion is made of four classes of neurons, distinct from both sympathetic and parasympathetic ones, albeit with a kinship to the former, but not the latter, through a complex genetic signature. We also show that spinal lumbar preganglionic neurons synapse in the pelvic ganglion onto equal numbers of noradrenergic and cholinergic cells, both of which therefore serve as sympathetic relays. Thus, the pelvic viscera receive no innervation from parasympathetic or typical sympathetic neurons, but instead from a divergent tail end of the sympathetic chains, in charge of its idiosyncratic functions.
摘要：
盆腔器官(膀胱，直肠,和性器官）已经代表了一个世纪，因为通过共享的接力从两个途径接受自主神经支配-腰交感神经和骶骨副交感神经，骨盆神经节,被认为是交感神经和副交感神经元的集合。使用单细胞RNA测序，我们发现小鼠骨盆神经节由四类神经元组成，不同于交感神经和副交感神经，尽管与前者有血缘关系，但不是后者，通过复杂的遗传签名。我们还表明，脊柱腰椎节前神经元在骨盆神经节中突触到相等数量的去甲肾上腺素能和胆碱能细胞上，因此，两者都充当交感神经继电器。因此，盆腔内脏不接受来自副交感神经或典型交感神经元的神经支配，而是从交感神经链的不同尾端，负责其特殊功能。
