Abstract：
Amanita phalloides poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on Amanita phalloides mushroom poisoning cases. The extract of the Amanita phalloides mushroom was taken and intraperitoneally administered to male Wistar Albino rats at a dose of 0.3 g/kg. In the experiment phase, the rats were divided into three groups of CDP-choline treatment according to the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg, and one control group was administered a 1 ml/kg dose of 0.9% isotonic NaCl solution. The treatments were then administered intraperitoneally at the 2nd hour, and at the 6th hour, the rats were sacrificed. The degree of damage in the liver and kidney tissues of the rats was evaluated histopathologically. It was concluded that CDP-choline reduced or prevented the damage that occurred in the liver significantly and dose-dependently in the toxicosis picture caused by Amanita phalloides, and it showed a tendency to lower or prevent the damage in the kidney, albeit not significantly.
摘要：
众所周知，在蘑菇中毒病例中，天鹅膏中毒是最致命的病例。它的主要毒性机制是它通过其毒素与DNA依赖性RNA聚合酶II酶的不可逆结合而导致细胞死亡。本研究旨在分析CDP-胆碱分子对天鹅膏蘑菇中毒病例的影响。取蛇毒蘑菇的提取物，并以0.3g/kg的剂量腹膜内给予雄性Wistar白化病大鼠。在实验阶段,将大鼠按100mg/kg的剂量分为3组,250mg/kg,和500毫克/千克，对照组给予1ml/kg剂量的0.9%等渗NaCl溶液。然后在第2小时腹膜内给予治疗，在第六个小时，大鼠被处死。通过组织病理学评估大鼠肝脏和肾脏组织的损伤程度。结论是，CDP-胆碱显着和剂量依赖性地减少或预防了由天麻引起的中毒图像中肝脏发生的损害，它显示出降低或预防肾脏损伤的趋势，虽然不显著。
