Abstract：
OBJECTIVE: This study aimed to compare the effectiveness of an intensive treatment based on enhanced cognitive-behavioral therapy (CBT-E) in patients aged between 12 and 18 years with anorexia nervosa with a duration of illness <3 versus ≥3 years.
METHODS: One hundred and fifty-nine consecutively treated patients (n = 122 with illness duration <3 years and n = 37 ≥ 3 years) were enrolled in a 20-week intensive CBT-E program. All patients underwent assessment at admission, end of treatment (EOT), and 20-week follow-up. The following measures were used: body mass index (BMI)-for-age percentile and percentage of expected body weight (EBW), Eating Disorder Examination Questionnaire, Brief Symptom Inventory, and Clinical Impairment Assessment.
RESULTS: Approximately 81% of eligible patients began the program, with over 80% successfully completing it. Patients with a longer or shorter duration of illness did not show significantly different treatment outcomes. In detail, BMI-for-age percentile and percentage of EBW outcomes were significantly improved from baseline to EOT, remaining stable until 20-week follow-up in both groups. Similarly, in both groups, scores for eating disorder psychopathology, general psychopathology, and clinical impairment decreased significantly at EOT and remained stable from EOT to follow-up. Furthermore, a substantial percentage of adolescents in both groups achieved a good BMI outcome at EOT and 20-week follow-up, with approximately 60% maintaining a full response at the latter time point.
CONCLUSIONS: These findings suggest that intensive CBT-E appears to be an effective treatment for severely ill adolescent patients with anorexia nervosa, regardless of whether the duration of illness is shorter or longer than 3 years.
UNASSIGNED: Existing treatment outcome studies in adolescents, whether randomized controlled trials or longitudinal investigations, typically involve patients with less than 3 years of illness, while data on the treatment outcomes for adolescents with anorexia nervosa with an illness duration of 3 years or over is very limited. Our findings suggest that adolescents with anorexia nervosa, irrespective of the duration of their illness, can derive similar benefits from intensively CBT-E.
METHODS: One hundred and fifty-nine consecutively treated patients (n = 122 with illness duration <3 years and n = 37 ≥ 3 years) were enrolled in a 20-week intensive CBT-E program. All patients underwent assessment at admission, end of treatment (EOT), and 20-week follow-up. The following measures were used: body mass index (BMI)-for-age percentile and percentage of expected body weight (EBW), Eating Disorder Examination Questionnaire, Brief Symptom Inventory, and Clinical Impairment Assessment.
RESULTS: Approximately 81% of eligible patients began the program, with over 80% successfully completing it. Patients with a longer or shorter duration of illness did not show significantly different treatment outcomes. In detail, BMI-for-age percentile and percentage of EBW outcomes were significantly improved from baseline to EOT, remaining stable until 20-week follow-up in both groups. Similarly, in both groups, scores for eating disorder psychopathology, general psychopathology, and clinical impairment decreased significantly at EOT and remained stable from EOT to follow-up. Furthermore, a substantial percentage of adolescents in both groups achieved a good BMI outcome at EOT and 20-week follow-up, with approximately 60% maintaining a full response at the latter time point.
CONCLUSIONS: These findings suggest that intensive CBT-E appears to be an effective treatment for severely ill adolescent patients with anorexia nervosa, regardless of whether the duration of illness is shorter or longer than 3 years.
UNASSIGNED: Existing treatment outcome studies in adolescents, whether randomized controlled trials or longitudinal investigations, typically involve patients with less than 3 years of illness, while data on the treatment outcomes for adolescents with anorexia nervosa with an illness duration of 3 years or over is very limited. Our findings suggest that adolescents with anorexia nervosa, irrespective of the duration of their illness, can derive similar benefits from intensively CBT-E.
摘要：
目的：本研究旨在比较基于强化认知行为疗法(CBT-E)的强化治疗对12至18岁、病程<3年和≥3年的神经性厌食症患者的疗效。
方法：在一项为期20周的强化CBT-E计划中纳入了一百五十九名连续治疗的患者（n=122，病程<3年，n=37≥3年）。所有患者在入院时接受评估，治疗结束（EOT），和20周的随访。使用以下措施：体重指数（BMI）-年龄百分位数和预期体重百分比（EBW），饮食失调检查问卷，简要症状清单，和临床损害评估。
结果：大约81％的合格患者开始了该计划，超过80%成功完成。疾病持续时间较长或较短的患者没有显示出明显不同的治疗结果。详细来说,从基线到EOT，BMI/年龄百分位数和EBW结局百分比显着改善，两组在20周随访前保持稳定。同样，在这两组中，饮食失调精神病理学的分数，一般精神病理学，在EOT时，临床损害显着下降，从EOT到随访保持稳定。此外，两组中相当比例的青少年在EOT和20周随访时获得了良好的BMI结果，大约60%的人在后一个时间点保持完全反应。
结论：这些研究结果表明，强化CBT-E似乎是治疗青少年重症神经性厌食症的有效方法，无论病程是否短于或长于3年。
■现有的青少年治疗结果研究，无论是随机对照试验还是纵向调查，通常涉及患病少于3年的患者，而病程在3年或以上的青少年神经性厌食症的治疗结果数据非常有限。我们的研究结果表明，患有神经性厌食症的青少年，不管他们患病的时间长短,可以从密集的CBT-E中获得类似的好处。
方法：在一项为期20周的强化CBT-E计划中纳入了一百五十九名连续治疗的患者（n=122，病程<3年，n=37≥3年）。所有患者在入院时接受评估，治疗结束（EOT），和20周的随访。使用以下措施：体重指数（BMI）-年龄百分位数和预期体重百分比（EBW），饮食失调检查问卷，简要症状清单，和临床损害评估。
结果：大约81％的合格患者开始了该计划，超过80%成功完成。疾病持续时间较长或较短的患者没有显示出明显不同的治疗结果。详细来说,从基线到EOT，BMI/年龄百分位数和EBW结局百分比显着改善，两组在20周随访前保持稳定。同样，在这两组中，饮食失调精神病理学的分数，一般精神病理学，在EOT时，临床损害显着下降，从EOT到随访保持稳定。此外，两组中相当比例的青少年在EOT和20周随访时获得了良好的BMI结果，大约60%的人在后一个时间点保持完全反应。
结论：这些研究结果表明，强化CBT-E似乎是治疗青少年重症神经性厌食症的有效方法，无论病程是否短于或长于3年。
■现有的青少年治疗结果研究，无论是随机对照试验还是纵向调查，通常涉及患病少于3年的患者，而病程在3年或以上的青少年神经性厌食症的治疗结果数据非常有限。我们的研究结果表明，患有神经性厌食症的青少年，不管他们患病的时间长短,可以从密集的CBT-E中获得类似的好处。
