Abstract：
The National Reference Laboratory in Clinical Mycology of Argentina conducted a retrospective review of human coccidioidomycosis cases diagnosed by the National Mycology Laboratory Network of Argentina between 2010 and 2022 to determine the burden of the disease in the country. A total of 100 human coccidioidomycosis cases were documented, with a higher prevalence in male patients (male-to-female ratio of 1.9:1), with a median age of 41 years. Comparing the number of cases between two 10-year periods (2000-2009 and 2010-2019), the increase was 36.51% (from 63 to 86 cases). Among the 100 recorded cases, 79 tested positive using the double immunodiffusion test. Spherules were observed in 19 cases through histopathology or direct microscopic examination and the fungus was isolated in 39 cases. Thirty-six isolates were identified as Coccidioides posadasii through partial sequencing of the Ag2/PRA gene. Catamarca province had the highest number of cases, comprising 64% of the total, with an incidence rate above 1.0-2.5/100,000 inhabitants until 2018. However, there has been a recent downward trend in the region from 2018 to 2022. It is concerning that more than half of diagnosed cases were chronic pulmonary or disseminated forms, indicating a lack of early disease detection. To rectify this issue, it is imperative to conduct targeted training programs for healthcare personnel and enhance public awareness within the endemic area. This will contribute to a better understanding of the true burden of coccidioidomycosis and enable the implementation of appropriate sanitary control measures.
摘要：
阿根廷国家临床真菌学参考实验室对2010年至2022年间由阿根廷国家真菌学实验室网络诊断的人类球孢子菌病病例进行了回顾性审查，以确定该疾病在该国的负担。共记录了100例人球虫菌病病例,男性患者的患病率较高（男女比例为1.9：1），平均年龄为41岁。比较两个十年期(2000-2009年和2010-2019年)的病例数，增加了36.51％（从63例增加到86例）。在记录的100个案例中，79使用双重免疫扩散试验检测为阳性。通过组织病理学或直接显微镜检查观察到19例球形，分离出真菌39例。通过对Ag2/PRA基因进行部分测序，将36个分离株鉴定为球虫。卡塔马卡省的病例最多,占总数的64%，在2018年之前，发病率高于1.0-2.5/100,000居民。然而,从2018年到2022年，该地区最近出现了下降趋势。令人担忧的是，超过一半的确诊病例是慢性肺部或播散型，表明缺乏早期疾病检测。为了纠正这个问题，必须为医护人员开展有针对性的培训计划，并提高流行地区的公众意识。这将有助于更好地了解球孢子菌病的真正负担，并能够实施适当的卫生控制措施。
我们在2010年至2022年期间对阿根廷的人类球孢子菌病病例进行了回顾性审查。我们记录了100例,其中64％来自卡塔马卡省。大量确诊病例为慢性肺性或播散性,表明缺乏早期检测。
我们在2010年至2022年期间对阿根廷的人类球孢子菌病病例进行了回顾性审查。我们记录了100例,其中64％来自卡塔马卡省。大量确诊病例为慢性肺性或播散性,表明缺乏早期检测。
