PDF(Pubmed)
Abstract：
Recent studies have established the moment-to-moment turnover of the blood-oxygen-level-dependent signal (TBOLD) at resting state as a key measure of local cortical brain function. Here, we sought to extend that line of research by evaluating TBOLD in 70 cortical areas with respect to corresponding brain volume, age, and sex across the lifespan in 1,344 healthy participants including 633 from the Human Connectome Project (HCP)-Development cohort (294 males and 339 females, age range 8-21 yr) and 711 healthy participants from HCP-Aging cohort (316 males and 395 females, 36-90 yr old). In both groups, we found that 1) TBOLD increased with age, 2) volume decreased with age, and 3) TBOLD and volume were highly significantly negatively correlated, independent of age. The inverse association between TBOLD and volume was documented in nearly all 70 brain areas and for both sexes, with slightly stronger associations documented for males. The strong correspondence between TBOLD and volume across age and sex suggests a common influence such as chronic neuroinflammation contributing to reduced cortical volume and increased TBOLD across the lifespan.NEW & NOTEWORTHY We report a significant negative association between resting functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) signal turnover (TBOLD) and cortical gray matter volume across the lifespan, such that TBOLD increased whereas volume decreased. We attribute this association to a hypothesized chronic, low-grade neuroinflammation, probably induced by various neurotropic pathogens, including human herpes viruses known to be dormant in the brain in a latent state and reactivated by stress, fever, and various environmental exposures, such as ultraviolet light.
摘要：
最近的研究已经建立了静息状态下血氧水平依赖性信号（TBOLD）的即时转换，作为局部皮质脑功能的关键量度。这里,我们试图通过评估70个皮质区域的TBOLD相对于相应的脑体积来扩展研究线，年龄,1,344名健康参与者的寿命和性别，其中633名来自人类连接组项目（HCP）-发展队列（294名男性和339名女性，年龄范围8-21岁)和711名来自HCP-Aging队列的健康参与者(316名男性和395名女性，36-90岁)。在这两组中,我们发现1)TBOLD随着年龄的增长而增加，2)体积随着年龄的增长而减少，3)TBOLD和体积呈高度显著负相关，独立于年龄。TBOLD和体积之间的负相关记录在几乎所有70个大脑区域和两性，与男性有更强的关联。跨年龄和性别的TBOLD与体积之间的强烈对应关系表明了共同的影响，例如慢性神经炎症导致整个生命周期中皮质体积减少和TBOLD增加。我们报告了整个生命周期中静息功能磁共振成像（fMRI）血氧水平依赖性（BOLD）信号转换（TBOLD）与皮质灰质体积之间的显着负相关，这样TBOLD增加而体积减少。我们将这种联系归因于假设的慢性，低度神经炎症,可能是由各种嗜神经病原体引起的，包括已知在大脑中处于潜伏状态并因压力而重新激活的人类疱疹病毒，发烧,和各种环境暴露，如紫外线。
