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Abstract：
OBJECTIVE: The relationship between skeletal muscle and adipose tissue compositions and risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) treatment needs to be investigated.
METHODS: A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 months and the first-year results of all patients after TIPS therapy were collected. The muscle and adipose tissue indices were quantified at the third lumbar vertebra level. Sarcopenia and myosteatosis were defined according to previous researches. Receiver operating characteristic curves, chi-square test, univariate and multivariate logistic regression analyses were employed to investigate the potential association between muscle and adipose indices, sarcopenia, myosteatosis and the risk of developing post-TIPS OHE.
RESULTS: All skeletal muscle indices, adipose tissue indices and sarcopenia had limited associations with post-TIPS OHE. Myosteatosis (148 cases, 52.5%, 55 with OHE, 37.2%) was identified as an independent risk factor for post-TIPS OHE. with P < 0.001 in Chi-square test, P < 0.001, odds ratio (OR): 2.854, 95% confidence interval (CI): 1.632-4.993 in univariate logistic regression analyses, and P = 0.007, OR: 2.372, 95% CI: 1.268-4.438 in multivariate logistic regression analyses, respectively.
CONCLUSIONS: Our results showed that myosteatosis was proven as an independent risk factor for the development of post-TIPS OHE.
METHODS: A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 months and the first-year results of all patients after TIPS therapy were collected. The muscle and adipose tissue indices were quantified at the third lumbar vertebra level. Sarcopenia and myosteatosis were defined according to previous researches. Receiver operating characteristic curves, chi-square test, univariate and multivariate logistic regression analyses were employed to investigate the potential association between muscle and adipose indices, sarcopenia, myosteatosis and the risk of developing post-TIPS OHE.
RESULTS: All skeletal muscle indices, adipose tissue indices and sarcopenia had limited associations with post-TIPS OHE. Myosteatosis (148 cases, 52.5%, 55 with OHE, 37.2%) was identified as an independent risk factor for post-TIPS OHE. with P < 0.001 in Chi-square test, P < 0.001, odds ratio (OR): 2.854, 95% confidence interval (CI): 1.632-4.993 in univariate logistic regression analyses, and P = 0.007, OR: 2.372, 95% CI: 1.268-4.438 in multivariate logistic regression analyses, respectively.
CONCLUSIONS: Our results showed that myosteatosis was proven as an independent risk factor for the development of post-TIPS OHE.
摘要：
目的：需要研究经颈静脉肝内门体分流术（TIPS）治疗后骨骼肌和脂肪组织成分与明显肝性脑病（OHE）风险之间的关系。
方法：从两个医疗中心收集了282例患者。中位随访时间为48.23±1.36个月，收集TIPS治疗后所有患者的第一年结果。在第三腰椎水平对肌肉和脂肪组织指数进行定量。根据先前的研究，定义了肌肉减少症和肌肉骨化症。接收机工作特性曲线,卡方检验,单变量和多变量逻辑回归分析用于研究肌肉和脂肪指数之间的潜在关联，少肌症,肌肉骨化和发展后TIPSOHE的风险。
结果：所有骨骼肌指数，脂肪组织指数和肌少症与TIPS术后OHE的相关性有限.肌肉骨化（148例，52.5%,55与OHE37.2%)被确定为TIPS术后OHE的独立危险因素。卡方检验P<0.001，P<0.001，比值比（OR）：2.854，95％置信区间（CI）：1.632-4.993在单变量逻辑回归分析，和P=0.007，OR：2.372，95％CI：1.268-4.438在多变量逻辑回归分析中，分别。
结论：我们的结果表明，肌骨形成已被证明是TIPS后OHE发展的独立危险因素。
方法：从两个医疗中心收集了282例患者。中位随访时间为48.23±1.36个月，收集TIPS治疗后所有患者的第一年结果。在第三腰椎水平对肌肉和脂肪组织指数进行定量。根据先前的研究，定义了肌肉减少症和肌肉骨化症。接收机工作特性曲线,卡方检验,单变量和多变量逻辑回归分析用于研究肌肉和脂肪指数之间的潜在关联，少肌症,肌肉骨化和发展后TIPSOHE的风险。
结果：所有骨骼肌指数，脂肪组织指数和肌少症与TIPS术后OHE的相关性有限.肌肉骨化（148例，52.5%,55与OHE37.2%)被确定为TIPS术后OHE的独立危险因素。卡方检验P<0.001，P<0.001，比值比（OR）：2.854，95％置信区间（CI）：1.632-4.993在单变量逻辑回归分析，和P=0.007，OR：2.372，95％CI：1.268-4.438在多变量逻辑回归分析中，分别。
结论：我们的结果表明，肌骨形成已被证明是TIPS后OHE发展的独立危险因素。
