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Abstract：
Aim: Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials & methods: least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification. Results: A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0.81. miR-223 was found to be hypomethylated in 160 HCC tissues, and its methylation level was associated with Barcelona Clinic Liver Cancer stages and the prognosis of patients with HCC. Conclusion: The prognostic model based on miRNA methylation levels has the capability to partially forecast the prognosis of patients with HCC.
摘要：
目的：利用miRNA基因的甲基化水平建立肝细胞癌（HCC）患者的预后模型。材料和方法：进行最小绝对收缩和选择算子和多变量Cox回归分析以建立预后模型。选择模型中的一个miRNA进行验证。结果：使用8种miRNA建立了预后模型。预测1、3和5年总生存期的曲线下面积分别为0.75、0.81和0.81。在160个HCC组织中发现miR-223低甲基化，其甲基化水平与巴塞罗那临床肝癌分期和肝癌患者的预后相关。结论：基于miRNA甲基化水平的预后模型能够部分预测HCC患者的预后。
