%0 Journal Article
%T Construction of a prognostic model based on genome-wide methylation analysis of miRNAs for hepatocellular carcinoma.
%A Shi Z
%A Liu X
%A Li D
%A Fan X
%A He L
%A Zhou D
%A Lin H
%J Epigenomics
%V 0
%N 0
%D 2024 Mar 13
%M 38477016
%F 4.357
%R 10.2217/epi-2023-0365
%X Aim: Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials & methods: least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification. Results: A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0.81. miR-223 was found to be hypomethylated in 160 HCC tissues, and its methylation level was associated with Barcelona Clinic Liver Cancer stages and the prognosis of patients with HCC. Conclusion: The prognostic model based on miRNA methylation levels has the capability to partially forecast the prognosis of patients with HCC.