PDF(Pubmed)
Abstract：
OBJECTIVE: The present study aimed to investigate the predictive ability of selected adiposity indices, such as body mass index (BMI), waist-to-hip ratio (WHR), waist circumference (WC), and waist-to-height ratio (WHtR), for new-onset hypertension in metabolically healthy Taiwanese adults. The study also sought to establish sex-specific cutoff points for these indices and to analyze the risk of new-onset hypertension, taking into account sex and age.
METHODS: This prospective cohort study utilized the Taiwan Biobank database to examine metabolically healthy participants aged between 20 and 65 at baseline. Four adiposity indices, namely BMI, WHR, WC, and WHtR, were calculated and used to predict new-onset hypertension over 4 years. Receiver operating characteristics (ROCs) and areas under the curve (AUCs) were used to evaluate the effectiveness of the parameters in predicting new-onset hypertension over 4 years. Sex-specific cutoff points were identified and used to assess the risk of new-onset hypertension.
RESULTS: This study analyzed 13,375 participants over 4.28 years. The incidence of new-onset hypertension was 17.65%. The new-onset rate of hypertension was 34.39% in men and 65.61% in women. Adiposity indices effectively predict new-onset hypertension, with WHtR having the highest predictive value (i.e., AUC) for both sexes. The classification of participants into low and high categories for each adiposity index was based on sex-specific cutoff points, and the risk of new-onset hypertension was assessed according to sex and age. This study found that high adiposity indices predicted a significantly higher risk of new-onset hypertension in metabolically healthy adults. The risk was equal for both sexes. Young women had a higher risk of new-onset hypertension than middle-aged women when they were further categorized. All risk ratios of the indices in young women were over two-fold and significant.
CONCLUSIONS: According to the sex-specific cutoff point, high adiposity indices had a higher predictive value for new-onset hypertension in metabolically healthy Taiwanese young women.
METHODS: This prospective cohort study utilized the Taiwan Biobank database to examine metabolically healthy participants aged between 20 and 65 at baseline. Four adiposity indices, namely BMI, WHR, WC, and WHtR, were calculated and used to predict new-onset hypertension over 4 years. Receiver operating characteristics (ROCs) and areas under the curve (AUCs) were used to evaluate the effectiveness of the parameters in predicting new-onset hypertension over 4 years. Sex-specific cutoff points were identified and used to assess the risk of new-onset hypertension.
RESULTS: This study analyzed 13,375 participants over 4.28 years. The incidence of new-onset hypertension was 17.65%. The new-onset rate of hypertension was 34.39% in men and 65.61% in women. Adiposity indices effectively predict new-onset hypertension, with WHtR having the highest predictive value (i.e., AUC) for both sexes. The classification of participants into low and high categories for each adiposity index was based on sex-specific cutoff points, and the risk of new-onset hypertension was assessed according to sex and age. This study found that high adiposity indices predicted a significantly higher risk of new-onset hypertension in metabolically healthy adults. The risk was equal for both sexes. Young women had a higher risk of new-onset hypertension than middle-aged women when they were further categorized. All risk ratios of the indices in young women were over two-fold and significant.
CONCLUSIONS: According to the sex-specific cutoff point, high adiposity indices had a higher predictive value for new-onset hypertension in metabolically healthy Taiwanese young women.
摘要：
目的：本研究旨在调查选定肥胖指数的预测能力，例如体重指数（BMI），腰臀比（WHR），腰围（WC），和腰围高度比(WHtR)，代谢健康的台湾成年人的新发高血压。该研究还试图为这些指标建立特定性别的临界点，并分析新发高血压的风险。考虑到性别和年龄。
方法：这项前瞻性队列研究利用台湾生物库数据库来检查基线时年龄在20至65岁之间的代谢健康参与者。四个肥胖指数，即BMI，WHR,WC,和WHTR,计算并用于预测4年以上的新发高血压。受试者工作特征（ROC）和曲线下面积（AUC）用于评估参数在预测4年内新发高血压中的有效性。确定了性别特异性的临界点，并用于评估新发高血压的风险。
结果：本研究分析了超过4.28年的13,375名参与者。新发高血压的发生率为17.65%。男性高血压新发率为34.39%，女性为65.61%。脂肪指数可有效预测新发高血压，WHtR具有最高的预测值(即，AUC）适用于两性。每个肥胖指数的参与者分为低和高类别是基于性别特定的临界点，根据性别和年龄评估新发高血压的风险.这项研究发现，高肥胖指数预测代谢健康的成年人新发高血压的风险明显更高。男女的风险是相等的。进一步分类时，年轻女性患新发高血压的风险高于中年女性。年轻女性指数的所有风险比都超过两倍，而且很重要。
结论：根据特定性别的临界点，在代谢健康的台湾年轻女性中,高肥胖指数对新发高血压的预测价值更高.
方法：这项前瞻性队列研究利用台湾生物库数据库来检查基线时年龄在20至65岁之间的代谢健康参与者。四个肥胖指数，即BMI，WHR,WC,和WHTR,计算并用于预测4年以上的新发高血压。受试者工作特征（ROC）和曲线下面积（AUC）用于评估参数在预测4年内新发高血压中的有效性。确定了性别特异性的临界点，并用于评估新发高血压的风险。
结果：本研究分析了超过4.28年的13,375名参与者。新发高血压的发生率为17.65%。男性高血压新发率为34.39%，女性为65.61%。脂肪指数可有效预测新发高血压，WHtR具有最高的预测值(即，AUC）适用于两性。每个肥胖指数的参与者分为低和高类别是基于性别特定的临界点，根据性别和年龄评估新发高血压的风险.这项研究发现，高肥胖指数预测代谢健康的成年人新发高血压的风险明显更高。男女的风险是相等的。进一步分类时，年轻女性患新发高血压的风险高于中年女性。年轻女性指数的所有风险比都超过两倍，而且很重要。
结论：根据特定性别的临界点，在代谢健康的台湾年轻女性中,高肥胖指数对新发高血压的预测价值更高.
