PDF(Pubmed)
Abstract：
Chemotherapy is a well-established method for treating cancer, but it has limited effectiveness due to its high dosage and harmful side effects. To address this issue, researchers have explored the use of photothermal agent nanoparticles as carriers for precise drug release in vivo. In this study, three different sizes of polydopamine nanoparticles (PDA-1, PDA-2, and PDA-3) were synthesized and evaluated. PDA-2 was selected for its optimal size, encapsulation rate, and drug loading rate. The release of the drug from PDA-2@TAX was tested at different pH and NIR laser irradiation levels. The results showed that PDA-2@TAX released more readily in an acidic environment and exhibited a high photothermal conversion efficiency when exposed to an 808 nm laser. In vitro experiments on ovarian cancer cells demonstrated that PDA-2@TAX effectively inhibited cell proliferation, highlighting its potential for synergistic chemotherapy-photothermal treatment.
摘要：
化疗是一种公认的治疗癌症的方法，但由于其高剂量和有害副作用，它的有效性有限。为了解决这个问题，研究人员已经探索了使用光热剂纳米颗粒作为体内精确释放药物的载体。在这项研究中,合成并评价了三种不同大小的聚多巴胺纳米粒子(PDA-1,PDA-2和PDA-3).PDA-2因其最佳尺寸而被选中，包封率,和载药率。在不同的pH和NIR激光照射水平下测试药物从PDA-2@TAX的释放。结果表明，PDA-2@TAX在酸性环境中更容易释放，并且在暴露于808nm激光时表现出高的光热转换效率。卵巢癌细胞体外实验证明PDA-2@TAX能有效抑制细胞增殖,突出了其协同化疗-光热治疗的潜力。
