PDF(Pubmed)
Abstract：
Different efforts have been made to find better and less invasive methods for the diagnosis and prediction of oral cancer, such as the study of saliva as a source of biomarkers. The aim of this study was to perform a scoping review about salivary molecules that have been assessed as possible biomarkers for the diagnosis of oral squamous cell carcinoma (OSCC). A search was conducted using EBSCO, PubMed (MEDLINE), Scopus, and Web of Science. The research question was as follows: which molecules present in saliva have utility to be used as biomarkers for the early detection of oral cancer? Sixty-two studies were included. Over 100 molecules were assessed. Most of the markers were oriented towards the early diagnosis of OSCC and were classified based on their ability for detecting OSCC and oral potentially malignant disorders (OPMDs), OSCC outcome prediction, and the prediction of the malignant transformation of OPMDs. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 were the most studied, with almost all studies reporting high sensitivity and specificity values. TNF-α, IL-1β, IL-6 IL-8, LDH, and MMP-9 are the most promising salivary biomarkers. However, more studies with larger cohorts are needed before translating the use of these biomarkers to clinical settings.
摘要：
已经做出了不同的努力来寻找更好的和侵入性更小的方法来诊断和预测口腔癌，例如唾液作为生物标志物来源的研究。这项研究的目的是对唾液分子进行范围审查，这些分子已被评估为诊断口腔鳞状细胞癌（OSCC）的可能生物标志物。使用EBSCO进行了搜索，PubMed(MEDLINE),Scopus,和WebofScience。研究问题如下：唾液中存在的哪些分子可用作早期检测口腔癌的生物标志物？包括62项研究。评估了超过100个分子。大多数标志物都是针对OSCC的早期诊断，并根据其检测OSCC和口腔潜在恶性疾病（OPMD）的能力进行分类。OSCC结果预测，以及OPMDs恶性转化的预测。TNF-α,IL-1β,IL-6IL-8,LDH,MMP-9是研究最多的，几乎所有研究都报告了高灵敏度和特异性值。TNF-α,IL-1β,IL-6IL-8,LDH,和MMP-9是最有前途的唾液生物标志物。然而,在将这些生物标志物应用于临床设置之前,还需要更多具有更大队列的研究.
