PDF(Pubmed)
Abstract：
Acute lymphoblastic leukemia (ALL) and glioma are some of the most common malignancies, with ALL most often affecting children and glioma affecting adult men. Proangiogenic cytokines and growth factors play an important role in the development of both of these tumors. Glioma is characterized by an extremely extensive network of blood vessels, which continues to expand mainly in the process of neoangiogenesis, the direct inducers of which are cytokines from the family of vascular endothelial growth factors, i.e., vascular endothelial growth factor (VEGF-A) and its receptor vascular endothelial growth factor receptor 2 (VEGF-R2), as well as a cytokine from the fibroblast growth factor family, fibroblast growth factor 2 (FGF-2 or bFGF). Growth factors are known primarily for their involvement in the progression and development of solid tumors, but there is evidence that local bone marrow angiogenesis and increased blood vessel density are also present in hematological malignancies, including leukemias. The aim of this study was to examine changes in the concentrations of VEGF-A, VEGF-R2, and FGF-2 (with a molecular weight of 17 kDa) in a group of patients divided into specific grades of malignancy (glioma) and a control group; changes of VEGF-A and FGF-2 concentrations in childhood acute lymphoblastic leukemia and a control group; and to determine correlations between the individual proteins as well as the influence of the patient\'s age, diet, and other conditions that may place the patient in the risk group. During the statistical analysis, significant differences in concentrations were found between the patient and control groups in samples from people with diagnosed glioma and from children with acute lymphoblastic leukemia, but in general, there are no significant differences in the concentrations of VEGF-A, VEGF-R2, and FGF-2 between different grades of glioma malignancy. Among individuals treated for glioma, there was no significant impact from the patient\'s gender and age, consumption of food from plastic packaging, frequency of eating vegetables and fruit, smoking of tobacco products, the intensity of physical exercise, or the general condition of the body (Karnofsky score) on the concentrations of the determined cytokines and receptor. The listed factors do not bring about an actual increase in the risk of developing brain glioma.
摘要：
急性淋巴细胞白血病（ALL）和神经胶质瘤是一些最常见的恶性肿瘤，与所有最常影响儿童和胶质瘤影响成年男性。促血管生成细胞因子和生长因子在这两种肿瘤的发展中起重要作用。胶质瘤的特点是血管网络极其广泛，主要在新血管生成的过程中继续扩张，其直接诱导剂是来自血管内皮生长因子家族的细胞因子，即，血管内皮生长因子(VEGF-A)及其受体血管内皮生长因子受体2(VEGF-R2),以及成纤维细胞生长因子家族的细胞因子，成纤维细胞生长因子2（FGF-2或bFGF）。已知生长因子主要参与实体瘤的进展和发展。但有证据表明，血液恶性肿瘤中也存在局部骨髓血管生成和血管密度增加，包括白血病.这项研究的目的是检查VEGF-A浓度的变化，VEGF-R2和FGF-2（分子量为17kDa）在一组患者中分为特定的恶性肿瘤（神经胶质瘤）和对照组；儿童急性淋巴细胞白血病和对照组中VEGF-A和FGF-2浓度的变化；并确定各个蛋白之间的相关性以及患者年龄的影响，饮食，以及其他可能将患者置于风险组的情况。在统计分析过程中,在诊断为神经胶质瘤的人和急性淋巴细胞白血病的儿童的样本中，患者组和对照组之间的浓度存在显着差异。但总的来说,VEGF-A的浓度没有显著差异,VEGF-R2和FGF-2在不同级别的胶质瘤恶性程度之间。在接受神经胶质瘤治疗的个体中，患者的性别和年龄没有显著影响，从塑料包装中消费食品，吃蔬菜和水果的频率，吸烟的烟草制品，体育锻炼的强度，或身体的一般状况（Karnofsky评分）对确定的细胞因子和受体的浓度。列出的因素不会导致发生脑胶质瘤的风险实际增加。
