PDF(Pubmed)
Abstract：
Obesity is an important health concern in horses, along with humans and companion animals. Adipose tissue is an inflammatory organ that alters the insulin-signaling cascade, ultimately causing insulin dysregulation and impaired glucose metabolism. These disruptions can increase the risk of metabolic disease and laminitis in horses and may also impact energy metabolism during exercise. A single bout of exercise, along with chronic exercise conditioning, increases insulin sensitivity and glucose disposal via both contraction- and insulin-mediated glucose uptake pathways. Regular exercise also increases calorie expenditure, which can facilitate weight (as body fat) loss. This paper explores the metabolic pathways affected by adiposity, as well as discusses the impact of exercise on insulin metabolism in horses.
摘要：
肥胖是马的重要健康问题，以及人类和伴侣动物。脂肪组织是改变胰岛素信号级联的炎症器官，最终导致胰岛素失调和葡萄糖代谢受损。这些干扰会增加马代谢疾病和椎板炎的风险，也可能影响运动过程中的能量代谢。一次锻炼，随着慢性运动调节，通过收缩和胰岛素介导的葡萄糖摄取途径增加胰岛素敏感性和葡萄糖处置。经常锻炼也会增加卡路里消耗，这可以促进体重（如身体脂肪）减少。本文探讨了受肥胖影响的代谢途径，以及讨论运动对马胰岛素代谢的影响。
