PDF(Pubmed)
Abstract：
This prospective observational study aimed to investigate the utility of lung ultrasound (LUS) in diagnosing and managing pediatric respiratory infections, specifically focusing on viral, bacterial, and SARS-CoV-2 infections. Conducted over a period of 1 year and 8 months, this research involved 85 pediatric patients (showcasing a median age of 14 months) recruited based on specific criteria, including age, confirmed infection through multiplex PCR tests, and willingness to undergo LUS imaging. This study employed a 12-area scoring system for LUS examinations, utilizing the lung ultrasound score (LUSS) to evaluate lung abnormalities. The PCR examination results reveal diverse respiratory pathogens, with SARS-CoV-2, influenza, and bacterial co-infections being prominent among the cases. As an observational study, this study was not registered in the registry. Distinct LUS patterns associated with different pathogens were identified, showcasing the discriminatory potential of LUS in differentiating between viral and bacterial etiologies. Bacterial infections demonstrated more severe lung involvement, evident in significantly higher LUSS values compared with viral cases (p < 0.0001). The specific abnormalities found in bacterial superinfection can be integrated into diagnostic and management protocols for pediatric respiratory infections. Overall, this research contributes valuable insights into optimizing LUS as a diagnostic tool in pediatric pneumonia, facilitating more informed and tailored healthcare decisions.
摘要：
这项前瞻性观察性研究旨在研究肺部超声（LUS）在诊断和管理小儿呼吸道感染中的应用。特别关注病毒，细菌,和SARS-CoV-2感染。为期1年零8个月，这项研究涉及根据特定标准招募的85名儿科患者（显示中位年龄为14个月），包括年龄,通过多重PCR测试确认感染，并愿意接受LUS成像。这项研究采用了12个区域的LUS考试评分系统，利用肺部超声评分（LUSS）评估肺部异常。PCR检测结果显示呼吸道病原体多样,SARS-CoV-2，流感，病例中细菌共感染突出。作为一项观察性研究，这项研究未在登记处注册.确定了与不同病原体相关的不同LUS模式，展示了LUS在区分病毒和细菌病因方面的鉴别潜力。细菌感染表现出更严重的肺部受累，与病毒性病例相比，LUSS值显着升高（p<0.0001）。细菌重复感染中发现的特定异常可以整合到儿科呼吸道感染的诊断和管理方案中。总的来说,这项研究有助于优化LUS作为小儿肺炎的诊断工具，促进更明智和量身定制的医疗保健决策。
