Abstract：
OBJECTIVE: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.
METHODS: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.
RESULTS: Among 2,385 participants, mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).
CONCLUSIONS: Physical function is impaired for many individuals with SSc and associated with multiple disease factors.
METHODS: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.
RESULTS: Among 2,385 participants, mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).
CONCLUSIONS: Physical function is impaired for many individuals with SSc and associated with multiple disease factors.
摘要：
目的：比较系统性硬化症的身体功能（SSc，硬皮病)对一般人群的规范性数据，并确定相关因素。
方法：以患者为中心的硬皮病干预网络队列参与者在注册时完成了患者报告结果测量信息系统版本2的身体功能域。多变量线性回归用于评估社会人口统计学，生活方式,和疾病相关变量。
结果：在2,385名参与者中，平均身体功能T评分(43.7,SD=8.9)比美国普通人群(平均值=50,SD=10)低~2/3的标准差(SD).多变量分析中的相关因素包括年龄较大(每SD年-0.74分，95%CI-0.78至-1.08），女性（-1.35，-2.37至-0.34），受教育年限较少(-0.41分，-0.75至-0.07)，单身,离婚,或丧偶(-0.76，-1.48至-0.03)，吸烟（-3.14，-4.42至-1.85），饮酒(每周每杯SD饮料0.79分，0.45-1.14),BMI(-1.41分/SD，-1.75至-1.07)，弥漫性亚型（-1.43，-2.23至-0.62），胃肠道受累（-2.58，-3.53至-1.62），数字溃疡（-1.96，-2.94至-0.98），中度（-1.94，-2.94至-0.93）和重度（-1.76，-3.24至-0.28）小关节挛缩，中度（-2.10，-3.44至-0.76）和重度（-2.54，-4.64至-0.44）大关节挛缩，间质性肺病（-1.52，-2.27至-0.77），肺动脉高压（-3.72，-4.91至-2.52），类风湿性关节炎（-2.10，-3.64至-0.56）和特发性炎性肌炎（-2.10，-3.63至-0.56）。
结论：许多SSc患者的身体功能受损，并与多种疾病因素相关。
方法：以患者为中心的硬皮病干预网络队列参与者在注册时完成了患者报告结果测量信息系统版本2的身体功能域。多变量线性回归用于评估社会人口统计学，生活方式,和疾病相关变量。
结果：在2,385名参与者中，平均身体功能T评分(43.7,SD=8.9)比美国普通人群(平均值=50,SD=10)低~2/3的标准差(SD).多变量分析中的相关因素包括年龄较大(每SD年-0.74分，95%CI-0.78至-1.08），女性（-1.35，-2.37至-0.34），受教育年限较少(-0.41分，-0.75至-0.07)，单身,离婚,或丧偶(-0.76，-1.48至-0.03)，吸烟（-3.14，-4.42至-1.85），饮酒(每周每杯SD饮料0.79分，0.45-1.14),BMI(-1.41分/SD，-1.75至-1.07)，弥漫性亚型（-1.43，-2.23至-0.62），胃肠道受累（-2.58，-3.53至-1.62），数字溃疡（-1.96，-2.94至-0.98），中度（-1.94，-2.94至-0.93）和重度（-1.76，-3.24至-0.28）小关节挛缩，中度（-2.10，-3.44至-0.76）和重度（-2.54，-4.64至-0.44）大关节挛缩，间质性肺病（-1.52，-2.27至-0.77），肺动脉高压（-3.72，-4.91至-2.52），类风湿性关节炎（-2.10，-3.64至-0.56）和特发性炎性肌炎（-2.10，-3.63至-0.56）。
结论：许多SSc患者的身体功能受损，并与多种疾病因素相关。
