{Reference Type}: Journal Article
{Title}: Factors associated with physical function among people with systemic sclerosis: a SPIN cohort cross-sectional study.
{Author}: Dal Santo T;Rice DB;Carrier ME;Virgili-Gervais G;Levis B;Kwakkenbos L;Golberg M;Bartlett SJ;Gietzen A;Gottesman K;Guillot G;Hudson M;Hummers LK;Malcarne VL;Mayes MD;Mouthon L;Richard M;Sauvé M;Wojeck RK;Geoffroy MC;Benedetti A;Thombs BD; ;
{Journal}: Rheumatology (Oxford)
{Volume}: 0
{Issue}: 0
{Year}: 2024 Mar 12
{Factor}: 7.046
{DOI}: 10.1093/rheumatology/keae162
{Abstract}: OBJECTIVE: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.
METHODS: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.
RESULTS: Among 2,385 participants, mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).
CONCLUSIONS: Physical function is impaired for many individuals with SSc and associated with multiple disease factors.