PDF(Pubmed)
Abstract：
Although fungi have been important model organisms for solving genetic, molecular, and ecological problems, recently, they are also becoming an important source of infectious disease. Despite their high medical burden, fungal pathogens are understudied, and relative to other pathogenic microbes, less is known about how their gene functions contribute to disease. This is due, in part, to a lack of powerful genetic tools to study these organisms. In turn, this has resulted in inappropriate treatments and diagnostics and poor disease management. There are a variety of reasons genetic studies were challenging in pathogenic fungi, but in recent years, most of them have been overcome or advances have been made to circumvent these barriers. In this minireview, we highlight how recent advances in genetic studies in fungal pathogens have resulted in the discovery of important biology and potential new antifungals and have created the tools to comprehensively study these important pathogens.
摘要：
尽管真菌一直是解决遗传的重要模式生物,分子，和生态问题，最近,它们也正在成为传染病的重要来源。尽管他们的医疗负担很高，真菌病原体研究不足，相对于其他病原微生物，人们对它们的基因功能如何导致疾病知之甚少。这是由于,在某种程度上,缺乏强大的遗传工具来研究这些生物。反过来,这导致了不适当的治疗和诊断以及不良的疾病管理.致病真菌遗传研究具有挑战性的原因有很多，但近年来,其中大多数已经被克服，或者已经取得了进展来规避这些障碍。在这篇小型评论中，我们重点介绍了真菌病原体遗传研究的最新进展如何发现了重要的生物学和潜在的新抗真菌药，并创造了全面研究这些重要病原体的工具。
