Abstract：
Nicotine use disorder remains a major public health emergency despite years of trumpeting the consequences of smoking. This is likely due to the complex interplay of genetics and nicotine exposure across the lifespan of these individuals. Genetics influence all aspects of life, including complex disorders such as nicotine use disorder. This review first highlights the critical neurocircuitry underlying nicotine dependence and withdrawal, and then describes the cellular signaling mechanisms involved. Finally, current genetic, genomic, and transcriptomic evidence for new drug development of smoking cessation aids is discussed, with a focus on the Neuregulin 3 Signaling Pathway.
摘要：
尽管多年来一直在吹嘘吸烟的后果，但尼古丁使用障碍仍然是主要的公共卫生紧急情况。这可能是由于遗传和尼古丁暴露在这些个体的寿命中的复杂相互作用。遗传学影响生活的各个方面，包括复杂的疾病，如尼古丁使用障碍。这篇综述首先强调了尼古丁依赖和戒断的关键神经回路，然后描述所涉及的细胞信号机制。最后,目前的遗传，基因组，讨论了戒烟辅助工具新药开发的转录组学证据，专注于神经调节蛋白3信号通路。
