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Abstract：
Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were assessed using enzyme-linked immunosorbent assay. The diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE were evaluated using receiver operating characteristic curve analysis. The results revealed that the serum and urine expression levels of Ang-2 and Tie2 were significantly elevated in HSP and pSLE patients, whereas the Ang-1/Ang-2 values were reduced. Additionally, Ang-1 was highly expressed in the serum and urine of HSP patients and in the serum of pSLE patients. Ang-1, Ang-2, and Tie2 showed differential expression in various types of HSP and pSLE compared with their expression in healthy controls. In summary, Ang-1, Ang-2, and Tie2 can serve as biomarkers for HSP and pSLE. Moreover, Ang-1/Ang-2 values are reduced in HSP and pSLE patients. Ang-1, Ang-2, and Tie2 can be used as biomarkers for HSP and pSLE.
摘要：
过敏性紫癜（HSP）和小儿发作性系统性红斑狼疮（pSLE）与血管炎和血管疾病密切相关。本研究旨在探讨Ang-1、Ang-2和Tie2对HSP和pSLE的临床诊断价值。我们调查了82例HSP患者，34pSLE患者，10个健康的孩子使用酶联免疫吸附试验评估血清和尿液中Ang-1，Ang-2和Tie2的表达水平。使用受试者工作特征曲线分析评估Ang-1，Ang-2和Tie2对HSP和pSLE的诊断价值。结果显示，HSP和pSLE患者血清和尿液中Ang-2和Tie2的表达水平明显升高，而Ang-1/Ang-2值降低。此外,Ang-1在HSP患者的血清和尿液以及pSLE患者的血清中高表达。Ang-1，Ang-2和Tie2在各种类型的HSP和pSLE中显示出差异表达，与健康对照组相比。总之,Ang-1、Ang-2和Tie2可作为HSP和pSLE的生物标志物。此外，在HSP和pSLE患者中Ang-1/Ang-2值降低。Ang-1、Ang-2和Tie2可用作HSP和pSLE的生物标志物。
