PDF(Pubmed)
Abstract：
UNASSIGNED: Overweight and obesity have become public health problems worldwide. An increasing number of research works are focusing on skin physiology and the manifestations of obesity-associated skin diseases, but little is known about the correlations between body mass index (BMI), facial skin physiological parameters, and the facial skin microbiome in healthy women.
UNASSIGNED: To investigate the correlations between BMI, facial skin physiological parameters and facial bacteria and fungi in 198 women aged 18 to 35 years in Shanghai.
UNASSIGNED: According to the international BMI standard and Chinese reference standard, subjects were divided into three groups, \"lean\" B1, \"normal\" B2 and \"overweight\" B3, and the physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiota was analyzed by 16S rRNA and ITS high-throughput sequencing.
UNASSIGNED: Compared with the skin physiological parameters of the normal group, those of the overweight group exhibited a significant increase in trans-epidermal water loss (TEWL), which indicated that the skin barrier was impaired. The skin haemoglobin content was significantly increased, and skin surface pH was significant decreased in those with a high BMI. Furthermore, α-diversity, analysed using the Shannon, Chao, Sobs, and Ace indexes, was increased in the overweight group, suggesting that the diversity and species abundance of facial bacterial and fungal microbiota were also increased. Moreover, the overweight group had higher abundances of Streptococcus, Corynebacterium, Malassezia, and Candida. Notably, skin surface pH was significantly and negatively correlated with the relative abundances of Malassezia, Candida, and Cladosporium. Besides, the abundance of Malassezia was positively associated with the abundances of Staphylococcus and Corynebacterium.
UNASSIGNED: These results indicate that BMI is associated with differences in the biophysical properties and microbiome of the facial skin. A high BMI affects the integrity of skin barrier and changes the skin flora diversity and species composition.
UNASSIGNED: To investigate the correlations between BMI, facial skin physiological parameters and facial bacteria and fungi in 198 women aged 18 to 35 years in Shanghai.
UNASSIGNED: According to the international BMI standard and Chinese reference standard, subjects were divided into three groups, \"lean\" B1, \"normal\" B2 and \"overweight\" B3, and the physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiota was analyzed by 16S rRNA and ITS high-throughput sequencing.
UNASSIGNED: Compared with the skin physiological parameters of the normal group, those of the overweight group exhibited a significant increase in trans-epidermal water loss (TEWL), which indicated that the skin barrier was impaired. The skin haemoglobin content was significantly increased, and skin surface pH was significant decreased in those with a high BMI. Furthermore, α-diversity, analysed using the Shannon, Chao, Sobs, and Ace indexes, was increased in the overweight group, suggesting that the diversity and species abundance of facial bacterial and fungal microbiota were also increased. Moreover, the overweight group had higher abundances of Streptococcus, Corynebacterium, Malassezia, and Candida. Notably, skin surface pH was significantly and negatively correlated with the relative abundances of Malassezia, Candida, and Cladosporium. Besides, the abundance of Malassezia was positively associated with the abundances of Staphylococcus and Corynebacterium.
UNASSIGNED: These results indicate that BMI is associated with differences in the biophysical properties and microbiome of the facial skin. A high BMI affects the integrity of skin barrier and changes the skin flora diversity and species composition.
摘要：
■超重和肥胖已成为全球公共卫生问题。越来越多的研究工作集中在皮肤生理学和肥胖相关皮肤病的表现上,但对身体质量指数(BMI)之间的相关性知之甚少，面部皮肤生理参数，和健康女性的面部皮肤微生物组。
■为了研究BMI，上海198名18至35岁女性面部皮肤生理参数及面部细菌和真菌。
■根据国际BMI标准和中国参考标准，受试者分为三组，“瘦”B1，“正常”B2和“超重”B3，并通过非侵入性仪器方法测量面部皮肤的生理参数，并通过16SrRNA和ITS高通量测序分析皮肤微生物群。
■与正常组的皮肤生理参数相比，超重组的人表现出经表皮失水（TEWL）的显着增加，这表明皮肤屏障受损。皮肤血红蛋白含量明显增加，高BMI的皮肤表面pH值显着降低。此外，α-多样性,用香农分析，Chao,Sobs,和Ace索引，超重组增加了，这表明面部细菌和真菌微生物群的多样性和物种丰度也增加了。此外，超重组的链球菌含量较高，棒状杆菌,马拉色菌,还有念珠菌.值得注意的是,皮肤表面pH值与马拉色菌的相对丰度呈显著负相关，念珠菌,和枝孢菌.此外,马拉色菌的丰度与葡萄球菌和棒状杆菌的丰度呈正相关。
■这些结果表明，BMI与面部皮肤的生物物理特性和微生物组的差异有关。高BMI会影响皮肤屏障的完整性，并改变皮肤菌群多样性和物种组成。
■为了研究BMI，上海198名18至35岁女性面部皮肤生理参数及面部细菌和真菌。
■根据国际BMI标准和中国参考标准，受试者分为三组，“瘦”B1，“正常”B2和“超重”B3，并通过非侵入性仪器方法测量面部皮肤的生理参数，并通过16SrRNA和ITS高通量测序分析皮肤微生物群。
■与正常组的皮肤生理参数相比，超重组的人表现出经表皮失水（TEWL）的显着增加，这表明皮肤屏障受损。皮肤血红蛋白含量明显增加，高BMI的皮肤表面pH值显着降低。此外，α-多样性,用香农分析，Chao,Sobs,和Ace索引，超重组增加了，这表明面部细菌和真菌微生物群的多样性和物种丰度也增加了。此外，超重组的链球菌含量较高，棒状杆菌,马拉色菌,还有念珠菌.值得注意的是,皮肤表面pH值与马拉色菌的相对丰度呈显著负相关，念珠菌,和枝孢菌.此外,马拉色菌的丰度与葡萄球菌和棒状杆菌的丰度呈正相关。
■这些结果表明，BMI与面部皮肤的生物物理特性和微生物组的差异有关。高BMI会影响皮肤屏障的完整性，并改变皮肤菌群多样性和物种组成。
