PDF(Pubmed)
Abstract：
In this research, palladium (II) and platinum (II), as well as their bimetallic nanoparticles were synthesized using medicinal plants in an eco-friendly manner. Rosemary and Ginseng extracts were chosen due to their promising anticancer potential. The synthesized nanoparticles underwent characterization through FT-IR spectroscopy, DLS, XRD, EDX, SEM, and TEM techniques. Once the expected structures were confirmed, the performance of these nanoparticles, which exhibited an optimal size, was evaluated as potential anticancer agents through in vitro method on colon cancer cell lines (Ls180, SW480). MTT assay studies showed that the synthesized nanoparticles induced cell death. Moreover, real-time PCR was employed to investigate autophagy markers and the effect of nanoparticles on the apoptosis process, demonstrating a significant effect of the synthesized compounds in this regard.
摘要：
在这项研究中,钯(II)和铂(II)，以及它们的双金属纳米颗粒是使用药用植物以生态友好的方式合成的。选择迷迭香和人参提取物是因为它们有前途的抗癌潜力。通过FT-IR光谱对合成的纳米粒子进行了表征，DLS,XRD,EDX,SEM,和TEM技术。一旦确认了预期的结构，这些纳米粒子的性能，表现出最佳尺寸，通过体外方法在结肠癌细胞系（Ls180，SW480）上评估作为潜在的抗癌剂。MTT实验研究表明，合成的纳米颗粒可诱导细胞死亡。此外，实时PCR检测自噬标志物和纳米颗粒对细胞凋亡过程的影响,证明了合成化合物在这方面的显著效果。
