Abstract：
Treatment of diabetic wounds is a major clinical issue. Diabetic wound dressings have higher requirements for anti-oxidant, antibacterial and wound monitoring properties compared to conventional wound dressings. In this study, a novel tannic acid (TA)/quaternized carboxymethyl chitosan (QCMCS)/oxidized sodium alginate (OSA)@carbon quantum dots (CQD) (TA/QCMCS/OSA@CQD) hydrogels for promoting diabetic wound healing and real-time monitoring have been developed. The TA/QCMCS/OSA@CQD hydrogels exhibited excellent self-healing, antibacterial and antioxidant properties. Besides, these hydrogels possessed good biocompatibility and effective hemostasis in a mouse liver injury model and significantly facilitated the healing process in a diabetic wound model. In addition, these hydrogels can reliable and timely measure the diabetic wound pH information by collecting image signals of hydrogels to monitor the healing status. Therefore, the pH responsive TA/QCMCS/OSA@CQD hydrogels could be utilized as wound dressing for promoting diabetic wound healing and real-time monitoring.
摘要：
糖尿病伤口的治疗是主要的临床问题。糖尿病伤口敷料对抗氧化剂有更高的要求,与常规伤口敷料相比，抗菌和伤口监测性能。在这项研究中,已经开发了一种新型的单宁酸（TA）/季铵化羧甲基壳聚糖（QCMCS）/氧化海藻酸钠（OSA）@碳量子点（CQD）（TA/QCMCS/OSA@CQD）水凝胶，用于促进糖尿病伤口愈合和实时监测。TA/QCMCS/OSA@CQD水凝胶表现出优异的自愈性,抗菌和抗氧化性能。此外,这些水凝胶在小鼠肝损伤模型中具有良好的生物相容性和有效的止血作用，并且在糖尿病伤口模型中显着促进了愈合过程。此外,这些水凝胶可以通过收集水凝胶的图像信号来监测愈合状态，从而可靠，及时地测量糖尿病伤口的pH信息。因此,pH响应性TA/QCMCS/OSA@CQD水凝胶可用作伤口敷料，用于促进糖尿病伤口愈合和实时监测。
