PDF(Pubmed)
Abstract：
BACKGROUND: The use of contraceptive methods is influenced by their effectiveness, availability, and minimal side effects. OCPs are one of the most effective and widely used methods of pregnancy prevention worldwide. This method not only prevents pregnancy but also helps prevent and treat other diseases. One of the main reasons for discontinuing this method is the emotional disturbances associated with its use. Lavender is an evergreen, fragrant plant that has gained significant attention for its anti-anxiety effects. This study was conducted to investigate the effect of lavender essential oil capsules on mood disorders during the use of COCs.
METHODS: This triple-blinded clinical trial was conducted on 60 married women (aged 15-49 years old) who were consumers of COCs, referring to 26 health centers in Tabriz, Iran. The participants were randomly assigned to either the intervention (consuming one gelatin capsule containing 80 mg LEO daily) or control (consuming one placebo capsule daily) group. The intervention continued for 56 days. Scores for positive and negative were determined using the Positive and Negative Affect Schedule (PANAS) questionnaire; and for stress, depression, and anxiety were measured using the DASS-21 questionnaire on day\'s 28th and 56th post-intervention. Data analysis was conducted using the t-test and ANOVA with repeated measures, and a p-value of < 0.05 was considered significant for all analyses.
RESULTS: A statistically significant difference was observed in mood disorders, stress, and depression between women receiving LEO or placebo. The consumption of LEO increased the positive mood on day 28 [MD (95% CI): 4.5 (2.1 to 7.0), p = 0.001] and day 56 [5.9 (3.4 to 8.3), p < 0.001] while decreased the negative mood on day 28 [MD (95% CI): -3.5 (-5.3 to -1.3), p < 0.001] and day 56 [-4.3 (-6.3 to -2.2), p < 0.001], stress on day 28 [MD (95% CI): -4.9 (-7.1 to -2.8), p = 0.001] and day 56 [-5.3 (-7.6 to -3.1), p < 0. 001], and depression on day 28 [MD (95% CI): -3.0 (-4.9 to 1.1), p = 0.003] and day 56 [-3.1 (-5.0 to 1.2), p = 0.002]. There was no statistically significant difference between the two groups in terms of anxiety.
CONCLUSIONS: The consumption of LEO with COCs improved mood disorders and reduced stress and depression. The use of hormonal contraceptives and mood changes should be considered by providers. Therefore, regarding the possibility of mood changes, it is expected that appropriate counseling and education will be provided to women who consume COC., providing appropriate solutions, including the simultaneous use of LEO.
METHODS: This triple-blinded clinical trial was conducted on 60 married women (aged 15-49 years old) who were consumers of COCs, referring to 26 health centers in Tabriz, Iran. The participants were randomly assigned to either the intervention (consuming one gelatin capsule containing 80 mg LEO daily) or control (consuming one placebo capsule daily) group. The intervention continued for 56 days. Scores for positive and negative were determined using the Positive and Negative Affect Schedule (PANAS) questionnaire; and for stress, depression, and anxiety were measured using the DASS-21 questionnaire on day\'s 28th and 56th post-intervention. Data analysis was conducted using the t-test and ANOVA with repeated measures, and a p-value of < 0.05 was considered significant for all analyses.
RESULTS: A statistically significant difference was observed in mood disorders, stress, and depression between women receiving LEO or placebo. The consumption of LEO increased the positive mood on day 28 [MD (95% CI): 4.5 (2.1 to 7.0), p = 0.001] and day 56 [5.9 (3.4 to 8.3), p < 0.001] while decreased the negative mood on day 28 [MD (95% CI): -3.5 (-5.3 to -1.3), p < 0.001] and day 56 [-4.3 (-6.3 to -2.2), p < 0.001], stress on day 28 [MD (95% CI): -4.9 (-7.1 to -2.8), p = 0.001] and day 56 [-5.3 (-7.6 to -3.1), p < 0. 001], and depression on day 28 [MD (95% CI): -3.0 (-4.9 to 1.1), p = 0.003] and day 56 [-3.1 (-5.0 to 1.2), p = 0.002]. There was no statistically significant difference between the two groups in terms of anxiety.
CONCLUSIONS: The consumption of LEO with COCs improved mood disorders and reduced stress and depression. The use of hormonal contraceptives and mood changes should be considered by providers. Therefore, regarding the possibility of mood changes, it is expected that appropriate counseling and education will be provided to women who consume COC., providing appropriate solutions, including the simultaneous use of LEO.
摘要：
背景：避孕方法的使用受到其有效性的影响，可用性,和最小的副作用。OCP是世界范围内最有效和广泛使用的妊娠预防方法之一。这种方法不仅可以防止怀孕，还可以帮助预防和治疗其他疾病。停止这种方法的主要原因之一是与其使用相关的情绪障碍。薰衣草是常青树，因其抗焦虑作用而受到关注的芳香植物。本研究旨在研究薰衣草精油胶囊对COCs使用过程中情绪障碍的影响。
方法：这项三盲临床试验是对60名已婚妇女（年龄15-49岁）进行的，这些妇女是COCs的消费者，指大不里士的26个健康中心，伊朗。参与者被随机分配到干预组（每天服用一个含有80mgLEO的明胶胶囊）或对照组（每天服用一个安慰剂胶囊）。干预持续了56天。积极和消极的分数是使用积极和消极的影响表（PANAS）问卷确定的;和压力，抑郁症,在干预后第28天和第56天使用DASS-21问卷测量焦虑。数据分析采用t检验和方差分析，重复测量，并且p值<0.05被认为对于所有分析是显著的。
结果：在情绪障碍中观察到统计学上的显着差异，压力，接受LEO或安慰剂的女性之间的抑郁症。LEO的消费增加了第28天的积极情绪[MD（95％CI）：4.5（2.1至7.0），p=0.001]和第56天[5.9（3.4至8.3），p<0.001]虽然在第28天减少了负面情绪[MD（95％CI）：-3.5（-5.3至-1.3），p<0.001]和第56天[-4.3（-6.3至-2.2），p<0.001],第28天的压力[MD（95%CI）：-4.9（-7.1至-2.8），p=0.001]和第56天[-5.3（-7.6至-3.1），p<0。001],第28天的抑郁症[MD（95%CI）：-3.0（-4.9至1.1），p=0.003]和第56天[-3.1（-5.0到1.2），p=0.002]。两组在焦虑方面无统计学差异。
结论：与COCs一起食用LEO改善了情绪障碍，减轻了压力和抑郁。提供者应考虑使用激素避孕药和情绪变化。因此,关于情绪变化的可能性，预计将向食用COC的妇女提供适当的咨询和教育。,提供适当的解决方案，包括同时使用LEO。
方法：这项三盲临床试验是对60名已婚妇女（年龄15-49岁）进行的，这些妇女是COCs的消费者，指大不里士的26个健康中心，伊朗。参与者被随机分配到干预组（每天服用一个含有80mgLEO的明胶胶囊）或对照组（每天服用一个安慰剂胶囊）。干预持续了56天。积极和消极的分数是使用积极和消极的影响表（PANAS）问卷确定的;和压力，抑郁症,在干预后第28天和第56天使用DASS-21问卷测量焦虑。数据分析采用t检验和方差分析，重复测量，并且p值<0.05被认为对于所有分析是显著的。
结果：在情绪障碍中观察到统计学上的显着差异，压力，接受LEO或安慰剂的女性之间的抑郁症。LEO的消费增加了第28天的积极情绪[MD（95％CI）：4.5（2.1至7.0），p=0.001]和第56天[5.9（3.4至8.3），p<0.001]虽然在第28天减少了负面情绪[MD（95％CI）：-3.5（-5.3至-1.3），p<0.001]和第56天[-4.3（-6.3至-2.2），p<0.001],第28天的压力[MD（95%CI）：-4.9（-7.1至-2.8），p=0.001]和第56天[-5.3（-7.6至-3.1），p<0。001],第28天的抑郁症[MD（95%CI）：-3.0（-4.9至1.1），p=0.003]和第56天[-3.1（-5.0到1.2），p=0.002]。两组在焦虑方面无统计学差异。
结论：与COCs一起食用LEO改善了情绪障碍，减轻了压力和抑郁。提供者应考虑使用激素避孕药和情绪变化。因此,关于情绪变化的可能性，预计将向食用COC的妇女提供适当的咨询和教育。,提供适当的解决方案，包括同时使用LEO。
