Abstract：
UNASSIGNED: Epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is an unusual vascular proliferation that tends to manifest in the head and neck region. Its occurrence on the penis is rare, with only scarce reported cases in the literature. The histopathological examination of this condition poses a challenge because it shares similarities with other entities, such as epithelioid hemangioendothelioma, epithelioid angiosarcoma, cutaneous epithelioid angiomatous nodule, or Kaposi sarcoma (KS). The infrequency of EH in penile locations underscores the need for accurate diagnostic differentiation and tailored treatment strategies for this atypical presentation. This case report highlights a rare instance of multifocal penile EH. The patient\'s lesions exhibited distinctive histopathologic features, with extensive eosinophilic infiltration, presence of necrosis, and infiltration to subcutaneous fat. The patient was treated with doxorubicin, a chemotherapy drug, with a very good response. This successful therapeutic outcome underscores the potential efficacy of doxorubicin in the management of multifocal penile EH. The comprehensive analysis of this case contributes to our understanding of the clinical presentation, histopathologic features, and treatment modalities for this rare penile tumor, providing valuable insights for future clinical considerations.
摘要：
■上皮样血管瘤（EH），也称为血管淋巴样增生伴嗜酸性粒细胞增多，是一种不寻常的血管增生，往往表现在头颈部。它在阴茎上的发生是罕见的，文献中只有很少报道的病例。这种情况的组织病理学检查提出了挑战，因为它与其他实体有相似之处，如上皮样血管内皮瘤，上皮样血管肉瘤，皮肤上皮样血管瘤结节，或卡波西肉瘤（KS）。EH在阴茎位置的发生率很低，这表明需要对这种非典型表现进行准确的诊断区分和量身定制的治疗策略。此病例报告突出了罕见的多灶性阴茎EH。患者的病变表现出独特的组织病理学特征，广泛的嗜酸性粒细胞浸润，坏死的存在，和皮下脂肪的浸润。患者接受了阿霉素治疗,化疗药物，有一个很好的回应。这种成功的治疗结果强调了阿霉素在多灶性阴茎EH治疗中的潜在功效。对这个病例的综合分析有助于我们对临床表现的理解,组织病理学特征,以及这种罕见阴茎肿瘤的治疗方式，为未来的临床考虑提供有价值的见解。
