Abstract：
The following questions guided the study: Can the use of fibrin glue in drainless rhytidoplasty reduce hematoma prevalence, seroma prevalence increase patient satisfaction or decrease the length of hospital in the adult population compared with standard treatment? The following inclusion and exclusion criteria apply: The procedure performed was rhytidoplasty for both groups. Participants were limited to adults who did not have any other procedure performed during the study. The intervention consisted of the use of fibrin glue without drains compared to the control group, in which drains and/or pressure dressing were applied. Databases: clinicaltrials.gov, MEDLINE, COCHRANE, mRCT, PubMed, Google Scholar, Scopus, Embase, VHL, GHL were searched on 03/25/2023 by 2 different investigators. The Cochrane Risk of Bias Tool 2.0 was used. Five studies were included with a total number of 1277 participants (2554 face sides). The cumulative hematoma rate was OR 0.47 (95% CI 0.26-0.84) in favor of using fibrin glue. Insufficient data were available to assess seroma rate, patient satisfaction, and length of hospital stay. The risk of study bias was judged to be low and moderate. The certainty for the use of fibrin sealant versus drainage is high and the importance of outcomes is rated as important in the GRADEpro GDT tool. Fibrin glue use is more beneficial comparing to drainage in patients undergoing rhytidectomy in terms of hematoma prevalence. This study was registered in PROSPERO (CRD42023421475).Level of Evidence I This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
摘要：
以下问题指导了该研究：纤维蛋白胶在无引流的输卵管成形术中的使用是否可以降低血肿的患病率，与标准治疗相比，血清肿患病率增加了患者的满意度或减少了成年人群的住院时间？以下纳入和排除标准适用：两组均进行了隆胎成形术。参与者仅限于在研究期间没有进行任何其他手术的成年人。与对照组相比，干预措施包括使用无引流的纤维蛋白胶，其中应用了排水沟和/或压力敷料。数据库:clinicaltrials.gov,MEDLINE,Cochrane,mRCT,PubMed,谷歌学者，Scopus,Embase,VHL,GHL于2023年3月25日由2名不同的调查人员进行了搜索。使用Cochrane偏差风险工具2.0。纳入了五项研究，共有1277名参与者（2554名面侧）。使用纤维蛋白胶的累积血肿率为OR0.47（95％CI0.26-0.84）。没有足够的数据来评估血清肿率，患者满意度,和住院时间。研究偏倚的风险被判断为低和中等。使用纤维蛋白密封剂与引流的确定性很高，并且在GRADeproGDT工具中，结果的重要性被认为很重要。在血肿患病率方面，接受除皱术的患者与引流相比，使用纤维蛋白胶更有益。本研究在PROSPERO（CRD42023421475）注册。证据级别I本期刊要求作者为每篇文章分配一个级别的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
