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Abstract：
OBJECTIVE: The aim of this study was to identify the risk factors for surgical site infection (SSI) in patients undergoing obstetrics and gynecology surgeries through meta-analysis.
METHODS: Relevant original studies published from January 1945 to May 2023 were searched the CBM, PubMed, Embase, WOS, CNKI, Wanfang, vip, and Cochrane Library databases. Studies eligible were evaluated by two investigators following Newcastle-Ottawa Scale(NOS) criteria. Review Manager 5.3 software was used to analyse the combined effect sizes and test for heterogeneity, and Stata 14.0 software\'s Begg\'s Test and Egger\'s Test were used to test for bias.
RESULTS: 13 case-control articles, including 860 cases in the case group and 13574 cases in the control group, met the inclusion criteria. Eventually, Our meta-analysis showed that SSI in patients undergoing obstetrics and gynecology surgeries was correlated with body mass index (BMI)≥24 (OR = 2.66; P < 0.0001), malignant lesions (OR = 4.65; P < 0.0001), operating time≥60min (OR = 2.58; P < 0.0001), intraoperative bleeding≥300ml (OR = 2.54; P < 0.0001), retained urinary catheter (OR = 4.45; P < 0.0001), and vaginal digital examination≥3times (OR = 2.52; P < 0.0001).
CONCLUSIONS: In this study, BMI≥24, intraoperative bleeding≥300ml, malignant lesions, operating time≥60min, retained urinary catheter, and vaginal digital examination≥3times were considered as independent risk factors for SSI in obstetrics and gynecology surgery. It is recommended that scholars be rigorous in designing the experimental process when conducting case-control or experimental studies in order to improve the quality of the study. Controlling patients\' weight before obstetrical and gynecological surgery, shortening the operation time intraoperatively, and strictly controlling the indications of vaginal digital examination and retained urinary catheter can effectively reduce the incidence of SSI.
METHODS: Relevant original studies published from January 1945 to May 2023 were searched the CBM, PubMed, Embase, WOS, CNKI, Wanfang, vip, and Cochrane Library databases. Studies eligible were evaluated by two investigators following Newcastle-Ottawa Scale(NOS) criteria. Review Manager 5.3 software was used to analyse the combined effect sizes and test for heterogeneity, and Stata 14.0 software\'s Begg\'s Test and Egger\'s Test were used to test for bias.
RESULTS: 13 case-control articles, including 860 cases in the case group and 13574 cases in the control group, met the inclusion criteria. Eventually, Our meta-analysis showed that SSI in patients undergoing obstetrics and gynecology surgeries was correlated with body mass index (BMI)≥24 (OR = 2.66; P < 0.0001), malignant lesions (OR = 4.65; P < 0.0001), operating time≥60min (OR = 2.58; P < 0.0001), intraoperative bleeding≥300ml (OR = 2.54; P < 0.0001), retained urinary catheter (OR = 4.45; P < 0.0001), and vaginal digital examination≥3times (OR = 2.52; P < 0.0001).
CONCLUSIONS: In this study, BMI≥24, intraoperative bleeding≥300ml, malignant lesions, operating time≥60min, retained urinary catheter, and vaginal digital examination≥3times were considered as independent risk factors for SSI in obstetrics and gynecology surgery. It is recommended that scholars be rigorous in designing the experimental process when conducting case-control or experimental studies in order to improve the quality of the study. Controlling patients\' weight before obstetrical and gynecological surgery, shortening the operation time intraoperatively, and strictly controlling the indications of vaginal digital examination and retained urinary catheter can effectively reduce the incidence of SSI.
摘要：
目的：本研究的目的是通过荟萃分析确定妇产科手术患者手术部位感染（SSI）的危险因素。
方法：从1945年1月至2023年5月发表的相关原始研究被搜索了CBM，PubMed,Embase,WOS,CNKI,万方,vip,和Cochrane图书馆数据库。符合资格的研究由两名研究人员根据纽卡斯尔-渥太华量表（NOS）标准进行评估。ReviewManager5.3软件用于分析综合效应大小，并测试异质性，Stata14.0软件的Begg测试和Egger测试用于测试偏差。
结果：13篇病例对照文章，其中病例组860例,对照组13574例,符合纳入标准。最终,我们的荟萃分析表明，妇产科手术患者的SSI与体重指数（BMI）≥24相关（OR=2.66；P<0.0001）。恶性病变（OR=4.65；P<0.0001），操作时间≥60min(OR=2.58;P<0.0001),术中出血≥300ml(OR=2.54;P<0.0001),留置导尿管(OR=4.45;P<0.0001),阴道指检≥3次(OR=2.52;P<0.0001)。
结论：在这项研究中，BMI≥24，术中出血≥300ml，恶性病变,操作时间≥60min,留置导尿管,阴道指式检查≥3次被认为是妇产科手术中发生SSI的独立危险因素。建议学者在进行病例对照或实验研究时，严格设计实验过程，以提高研究质量。在妇产科手术前控制患者体重，缩短术中手术时间，严格控制阴道指检及保留导尿管的指征,可有效降低SSI的发生率。
方法：从1945年1月至2023年5月发表的相关原始研究被搜索了CBM，PubMed,Embase,WOS,CNKI,万方,vip,和Cochrane图书馆数据库。符合资格的研究由两名研究人员根据纽卡斯尔-渥太华量表（NOS）标准进行评估。ReviewManager5.3软件用于分析综合效应大小，并测试异质性，Stata14.0软件的Begg测试和Egger测试用于测试偏差。
结果：13篇病例对照文章，其中病例组860例,对照组13574例,符合纳入标准。最终,我们的荟萃分析表明，妇产科手术患者的SSI与体重指数（BMI）≥24相关（OR=2.66；P<0.0001）。恶性病变（OR=4.65；P<0.0001），操作时间≥60min(OR=2.58;P<0.0001),术中出血≥300ml(OR=2.54;P<0.0001),留置导尿管(OR=4.45;P<0.0001),阴道指检≥3次(OR=2.52;P<0.0001)。
结论：在这项研究中，BMI≥24，术中出血≥300ml，恶性病变,操作时间≥60min,留置导尿管,阴道指式检查≥3次被认为是妇产科手术中发生SSI的独立危险因素。建议学者在进行病例对照或实验研究时，严格设计实验过程，以提高研究质量。在妇产科手术前控制患者体重，缩短术中手术时间，严格控制阴道指检及保留导尿管的指征,可有效降低SSI的发生率。
