Abstract：
Based on the current projection of the general population and the combined increase in end-stage kidney disease with age, the number of elderly donors and recipients is increasing, raising crucial questions about how to minimize the discard rate of organs from elderly donors and improve graft and patient outcomes. In 2002, extended criteria donors were the focus of a meeting in Crystal City (VA, USA), with a goal of maximizing the use of organs from deceased donors. Since then, extended criteria donors have progressively contributed to a large number of transplanted grafts worldwide, posing specific issues for allocation systems, recipient management, and therapeutic approaches. This review analyzes what we have learned in the last 20 years about extended criteria donor utilization, the promising innovations in immunosuppressive management, and the molecular pathways involved in the aging process, which constitute potential targets for novel therapies.
摘要：
根据目前对一般人群的预测和终末期肾病随年龄的增加，老年捐赠者和接受者的数量正在增加，提出了关于如何最大程度地减少老年供体器官的丢弃率并改善移植物和患者预后的关键问题。2002年，扩大标准的捐助者是水晶城会议的重点（VA，美国),目的是最大限度地利用已故捐献者的器官。从那以后,扩大标准的捐赠者逐渐为全世界大量移植移植物做出了贡献，为分配制度提出具体问题，收件人管理，和治疗方法。这篇综述分析了我们在过去20年中对扩大捐助者利用标准的了解，免疫抑制管理方面有前途的创新，以及衰老过程中涉及的分子途径，这构成了新疗法的潜在目标。
