UNASSIGNED: In this comparative cohort study, patients from the Swiss NeuroPaediatric Stroke Registry with ischemic stroke due to FCA-i between January 2000 and December 2018 were analyzed. A comparison between PC and AC cases regarding pediatric National Institutes of Health Stroke Scale score and pediatric stroke outcome measure and FCASS was performed. We estimated infarct size by the modified pediatric Alberta Stroke Program Early Computed Tomography Score in children with AC stroke and the adapted Bernese posterior diffusion-weighted imaging score in the PC.
UNASSIGNED: Thirty-five children with a median age of 6.3 (interquartile range, 2.7-8.2 [95% CI, 0.9-15.6]; 20 male; 57.1%) years with FCA-i were identified. The total incidence rate was 0.15/100 000/year (95% CI, 0.11-0.21). Six had PC-FCA-i. Time to final FCASS was longer in the PC compared with AC; the evolution of FCASS did not differ. Initial pediatric National Institutes of Health Stroke Scale score was higher in children with FCA-i in the PC with a median of 10.0 (interquartile range, 5.75-21.0) compared with 4.5 (interquartile range, 2.0-8.0) in those with AC-FCA-i. Different from the anterior cases, PC infarct volume did not correlate with higher discharge, maximum, or final FCASS scores (Pearson correlation coefficient [r], 0.25, 0.35, and 0.54).
UNASSIGNED: FCA-i also affects the PC. These cases should be included in future investigations into FCA-i. Although it did not correlate with clinical outcomes in our cohort, the modified FCASS may well serve as a marker for the evolution of the arteriopathy in posterior FCA-i.
■在这项比较队列研究中,我们分析了瑞士神经儿科卒中登记处2000年1月至2018年12月FCA-i导致缺血性卒中的患者.在PC和AC病例之间进行了关于儿科美国国立卫生研究院卒中量表评分和儿科卒中结果测量和FCASS的比较。我们通过改良的小儿Alberta卒中计划早期计算机断层扫描评分和PC中适应的Bernese后扩散加权成像评分来估计梗死面积。
■35名儿童,年龄中位数为6.3岁(四分位距,2.7-8.2[95%CI,0.9-15.6];20名男性;57.1%)岁的FCA-i被鉴定。总发病率为0.15/10万/年(95%CI,0.11~0.21)。六个有PC-FCA-i。与AC相比,PC的最终FCASS时间更长;FCASS的演变没有差异。最初的儿科美国国立卫生研究院卒中量表评分在PC中患有FCA-i的儿童中较高,中位数为10.0(四分位数范围,5.75-21.0)与4.5(四分位数间距,2.0-8.0)在具有AC-FCA-i的产品中。与前段病例不同,PC梗死体积与较高的排出量无关,最大值,或最终FCASS分数(皮尔逊相关系数[r],0.25、0.35和0.54)。
■FCA-i也会影响PC。这些案件应包括在今后对FCA-i的调查中。尽管它与我们队列中的临床结果无关,改良的FCASS很可能是后FCA-i动脉病变演变的标志。