PDF(Pubmed)
Abstract：
The incidence of lumbar disc herniation has gradually increased in recent years, and most patients have symptoms of low back pain and nerve compression, which brings a heavy burden to patients and society alike. Although the causes of disc herniation are complex, intervertebral disc degeneration (IDD) is considered to be the most common factor. The intervertebral disc (IVD) is composed of the upper and lower cartilage endplates, nucleus pulposus, and annulus fibrosus. Aging, abnormal mechanical stress load, and metabolic disorders can exacerbate the progression of IDD. Among them, high glucose and high-fat diets (HFD) can lead to fat accumulation, abnormal glucose metabolism, and inflammation, which are considered important factors affecting the homeostasis of IDD. Diabetes and advanced glycation end products (AGEs) accumulation- can lead to various adverse effects on the IVD, including cell senescence, apoptosis, pyroptosis, proliferation, and Extracellular matrix (ECM) degradation. While current research provides a fundamental basis for the treatment of high glucose-induced IDD patients. further exploration into the mechanisms of abnormal glucose metabolism affecting IDD and in the development of targeted drugs will provide the foundation for the effective treatment of these patients. We aimed to systematically review studies regarding the effects of hyperglycemia on the progress of IDD.
摘要：
近年来腰椎间盘突出症的发病率逐渐增高,大多数患者都有腰痛和神经压迫的症状，这给患者和社会带来了沉重的负担。虽然椎间盘突出的原因很复杂,椎间盘退变（IDD）被认为是最常见的因素。椎间盘(IVD)由上下软骨终板组成，髓核,和纤维环。衰老,异常机械应力载荷，代谢紊乱会加剧IDD的进展。其中,高葡萄糖和高脂肪饮食（HFD）可导致脂肪积累，葡萄糖代谢异常，和炎症，被认为是影响IDD稳态的重要因素。糖尿病和晚期糖基化终产物（AGEs）的积累-可导致对IVD的各种不利影响，包括细胞衰老,凋亡，焦亡,扩散,和细胞外基质(ECM)降解。而目前的研究为高糖诱导的IDD患者的治疗提供了基础。进一步探索糖代谢异常影响IDD的机制，并在靶向药物的开发方面为这些患者的有效治疗提供基础。我们旨在系统回顾有关高血糖对IDD进展的影响的研究。
