4 - {3 - [(吡啶 - 4 - 基甲基) 氨基] - [1, 2, 4] 三唑并 [4, 3 - b] [1, 2, 4] 三嗪 - 6 - 基} 苯酚: 肝细胞癌中改进的抗癌剂和选择性 MDR1 / MRP 调节剂。
关键词: MDR1 MRP1/2 c‐Met kinase inhibitor multidrug resistance triazolotriazine
Mesh : Humans Antineoplastic Agents / pharmacology chemical synthesis chemistry Liver Neoplasms / drug therapy pathology Carcinoma, Hepatocellular / drug therapy pathology Structure-Activity Relationship Multidrug Resistance-Associated Proteins / antagonists & inhibitors metabolism ATP Binding Cassette Transporter, Subfamily B / metabolism antagonists & inhibitors Drug Resistance, Neoplasm / drug effects Dose-Response Relationship, Drug Hep G2 Cells Molecular Structure Drug Resistance, Multiple / drug effects Cell Line, Tumor Proto-Oncogene Proteins c-met / antagonists & inhibitors metabolism Drug Screening Assays, Antitumor Cell Proliferation / drug effects Protein Kinase Inhibitors / pharmacology chemical synthesis chemistry Triazines / pharmacology chemistry chemical synthesis
来 源: DOI:10.1002/ardp.202300704