Abstract：
Endodontic therapy includes various procedures such as vital pulp therapy, root canal treatment and retreatment, surgical endodontic treatment and regenerative endodontic procedures. Disinfection and tissue repair are crucial for the success of these therapies, necessitating the development of therapeutics that can effectively target microbiota, eliminate biofilms, modulate inflammation and promote tissue repair. However, no current endodontic agents can achieve these goals. Antimicrobial peptides (AMPs), which are sequences of amino acids, have gained attention due to their unique advantages, including reduced susceptibility to drug resistance, broad-spectrum antibacterial properties and the ability to modulate the immune response of the organism effectively. This review systematically discusses the structure, mechanisms of action, novel designs and limitations of AMPs. Additionally, it highlights the efforts made by researchers to overcome peptide shortcomings and emphasizes the potential applications of AMPs in endodontic treatments.
摘要：
牙髓治疗包括各种程序，如重要的牙髓治疗，根管治疗和再治疗，外科牙髓治疗和再生牙髓手术。消毒和组织修复对于这些疗法的成功至关重要，需要开发能够有效靶向微生物群的疗法，消除生物膜，调节炎症并促进组织修复。然而,目前没有牙髓药可以实现这些目标。抗菌肽（AMP），它们是氨基酸的序列，由于其独特的优势而受到关注，包括降低对耐药性的敏感性，广谱抗菌特性和有效调节生物体免疫反应的能力。这篇综述系统地讨论了结构，行动机制,AMP的新颖设计和局限性。此外,它强调了研究人员为克服肽缺陷所做的努力，并强调了AMP在牙髓治疗中的潜在应用。
