Abstract：
Significance: Negative pressure wound therapy (NPWT) has been in practice for decades, proving its utility in many applications, ranging from acutely infected wounds to complex combat wounds and skin grafting. It has been routinely demonstrated that NPWT has superior wound healing outcomes compared with previous standard-of-care therapies. However, the technique involves some challenges related to each of the components that comprise the therapy. The purpose of this article is to highlight the challenges, introduce the recent advancements, and discuss about the future directions in NPWT systems. Recent Advances: New techniques and materials have been developed to improve the currently used NPWT systems with promising results when utilized with appropriate indications. Many advancements have been introduced in modes of negative pressure delivery, pumps, interface dressings, adhesive dressings, and tubing technology. Critical Issues: An optimal NPWT system would avoid the common problems such as failure to deliver negative pressure due to loss of an airtight seal or tissue ingrowth into the interface dressing causing painful dressing changes and bleeding. Other challenges include infection control and patient pain and discomfort that may contribute to noncompliance. Future Directions: Many studies have been performed to evaluate the optimal combination of settings and components in various wounds; however, there is still no clear \"best\" answer for many specific patient-wound scenarios. Novel and emerging tissue engineering and regenerative medicine approaches could potentially be utilized in the future NPWT systems and thus, this review will discuss some novel ideas for future considerations.
摘要：
结论：负压伤口治疗（NPWT）已经实践了几十年，证明了它在许多应用中的实用性，从严重感染的伤口到复杂的战斗伤口和植皮。常规证明,与先前的标准护理疗法相比,NPWT具有优异的伤口愈合结果。然而,该技术涉及与构成治疗的每个组件相关的一些挑战。本文的目的是强调挑战，介绍NPWT系统的最新进展，并讨论NPWT系统的未来发展方向。
背景：已经开发了新技术和材料来改进当前使用的NPWT系统，当与适当的适应症一起使用时，具有有希望的结果。在负压输送模式中引入了许多进步，泵,界面敷料,粘性敷料,和油管技术。
结果：最佳的NPWT系统可以避免常见的问题，例如由于失去气密密封或组织向内生长到界面敷料中导致痛苦的敷料更换和出血而无法输送负压。其他挑战包括感染控制和可能导致不依从性的患者疼痛和不适。
结论：已经进行了许多研究来评估各种伤口中设置和组件的最佳组合；但是，对于许多特定的患者伤口情况，仍然没有明确的“最佳”答案。新的和新兴的组织工程和再生医学方法可能被用于未来的NPWT系统，因此，这篇评论将讨论一些新颖的想法，以供将来考虑。
背景：已经开发了新技术和材料来改进当前使用的NPWT系统，当与适当的适应症一起使用时，具有有希望的结果。在负压输送模式中引入了许多进步，泵,界面敷料,粘性敷料,和油管技术。
结果：最佳的NPWT系统可以避免常见的问题，例如由于失去气密密封或组织向内生长到界面敷料中导致痛苦的敷料更换和出血而无法输送负压。其他挑战包括感染控制和可能导致不依从性的患者疼痛和不适。
结论：已经进行了许多研究来评估各种伤口中设置和组件的最佳组合；但是，对于许多特定的患者伤口情况，仍然没有明确的“最佳”答案。新的和新兴的组织工程和再生医学方法可能被用于未来的NPWT系统，因此，这篇评论将讨论一些新颖的想法，以供将来考虑。
