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Abstract：
The objective of this study was to review the clinical, radiologic, and histologic aspects of cases of dentigerous cysts metamorphosing into different entities along with comments on the molecular factors involved in the process. A series comprising 8 cases of dentigerous cysts was performed retrospectively along with a comprehensive literature review. Two cases of dentigerous cyst converting into mucous metaplasia were included, out of which one case was transformed into ameloblastoma after a year. The other two cases were reported as acanthomatous and unicystic ameloblastoma, whereas four transitioned to AOT. The complete review of cases and literature with molecular profiling concluded that the lining of dentigerous cysts has the potential for transforming into benign odontogenic tumors. Therefore, a careful clinical and histopathological examination is crucial for the correct diagnosis. Also, a thorough molecular understanding of the cystic lining is required.
摘要：
这项研究的目的是回顾临床，放射学,以及牙质囊肿变质成不同实体的病例的组织学方面，以及对该过程中涉及的分子因素的评论。回顾性地进行了包括8例牙科囊肿的系列研究，并进行了全面的文献综述。包括2例牙质囊肿转化为粘液上皮化生，其中一例在一年后转化为成釉细胞瘤。另外两例报告为棘皮瘤和单囊性成釉细胞瘤，而四个过渡到AOT。对病例和文献进行分子谱分析的完整回顾得出的结论是，牙质囊肿的衬里具有转化为良性牙源性肿瘤的潜力。因此,仔细的临床和组织病理学检查对于正确诊断至关重要。此外，需要对囊性衬里进行彻底的分子理解。
