PDF(Pubmed)
Abstract：
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.
摘要：
在B细胞监测时断奶时如何建立宿主-微生物互惠关系的机制仍未得到充分阐明。我们发现CD138浆细胞（PC）介导的IgA反应促进调节拟杆菌之间的共生关系（B.shiformis）和断奶期的寄主。CD138+PCs的IgA偏斜反应对于B.uniformis占据确定的肠道腔生态位至关重要，从而促进稳定的殖民。此外，在没有IgA的情况下，自然肠道生态位内的均匀性受到干扰，导致IgA缺陷小鼠和断奶仔猪的肠道炎症加剧。因此，我们认为CD138+PCs引发和维持肠道IgA反应是宿主-微生物共生所必需的，而其中的扰动会增强断奶过程中的炎症。
