%0 Journal Article
%T IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation.
%A Tang W
%A Wei Y
%A Ni Z
%A Hou K
%A Luo XM
%A Wang H
%J Gut Microbes
%V 16
%N 1
%D 2024 Jan-Dec
%M 38439579
%F 9.434
%R 10.1080/19490976.2024.2323220
%X The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates the symbiosis between Bacteroides uniformis (B. uniformis) and the host during the weaning period. The IgA-skewed response of CD138+ PCs is essential for B. uniformis to occupy a defined gut luminal niche, thereby fostering stable colonization. Furthermore, B. uniformis within the natural gut niche was perturbed in the absence of IgA, resulting in exacerbated gut inflammation in IgA-deficient mice and weaned piglets. Thus, we propose that the priming and maintenance of intestinal IgA response from CD138+ PCs are required for host-microbial symbiosis, whereas the perturbation of which would enhance inflammation in weaning process.