PDF(Pubmed)
Abstract：
BACKGROUND: Striae distensae is a disfiguring atrophic skin condition that impairs the body\'s aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchymal stem cells are considered a rich source for scar treatment. Skin needling is among the most efficient and safe aesthetic and therapeutic devices. This study aimed to evaluate the efficacy of the combination of needling and intradermal injection of mesenchymal stem cells compared to skin needling alone for treating striae distensae.
METHODS: This study was a randomized, double-blind clinical trial involving 10 women aged 18-60. Each striae lesion was divided into two parts, with one side receiving needling and intradermal injection of conditioned medium, while the other side received needling and intradermal injection of normal saline. This treatment was administered in three sessions with three-week intervals. Patients were evaluated before the first intervention and three months after the final session. Three months after the completion of the intervention, patients\' lesions were evaluated using biometric criteria, physician evaluation, and patient self-assessment.
RESULTS: The results demonstrated a significant improvement in dermal and complete thickness and skin density in patients treated with microneedling. All skin ultrasound parameters improved significantly in patients receiving the combination of needling and conditioned medium. When comparing the two groups, significantly higher physician and patient satisfaction was observed in the combination group. However, the comparison of biometric indices improvement wasn\'t significant between these groups.
CONCLUSIONS: The combination of human mesenchymal stem cells with microneedling could be considered a novel effective option for stretch marks.
METHODS: This study was a randomized, double-blind clinical trial involving 10 women aged 18-60. Each striae lesion was divided into two parts, with one side receiving needling and intradermal injection of conditioned medium, while the other side received needling and intradermal injection of normal saline. This treatment was administered in three sessions with three-week intervals. Patients were evaluated before the first intervention and three months after the final session. Three months after the completion of the intervention, patients\' lesions were evaluated using biometric criteria, physician evaluation, and patient self-assessment.
RESULTS: The results demonstrated a significant improvement in dermal and complete thickness and skin density in patients treated with microneedling. All skin ultrasound parameters improved significantly in patients receiving the combination of needling and conditioned medium. When comparing the two groups, significantly higher physician and patient satisfaction was observed in the combination group. However, the comparison of biometric indices improvement wasn\'t significant between these groups.
CONCLUSIONS: The combination of human mesenchymal stem cells with microneedling could be considered a novel effective option for stretch marks.
摘要：
背景：纹状体是一种毁容的萎缩性皮肤状况，会损害人体的美学形象。尽管进行了各种各样的研究，关于最佳模式存在争议。人类间充质干细胞被认为是瘢痕治疗的丰富来源。皮肤针刺是最有效和安全的美容和治疗设备之一。这项研究旨在评估与单独的皮肤针刺相比，针刺和皮内注射间充质干细胞联合治疗纹状体的疗效。
方法：这项研究是一项随机的，涉及10名18-60岁女性的双盲临床试验。每个纹状体病变分为两部分，一侧接受针刺和皮内注射条件培养基，另一侧接受针刺和皮内注射生理盐水。该治疗分三个疗程进行，间隔三周。在第一次干预之前和最后一次治疗后三个月对患者进行评估。干预完成三个月后，使用生物识别标准评估患者的病变，医师评估，和病人的自我评估。
结果：结果表明，使用微针治疗的患者的真皮和完全厚度以及皮肤密度有了显着改善。在接受针刺和条件培养基组合的患者中，所有皮肤超声参数均显着改善。当比较两组时，联合治疗组的医师和患者满意度明显更高.然而,这些组之间生物识别指数改善的比较并不显著。
结论：人骨髓间充质干细胞与微针结合可被认为是妊娠纹的一种新的有效选择。
方法：这项研究是一项随机的，涉及10名18-60岁女性的双盲临床试验。每个纹状体病变分为两部分，一侧接受针刺和皮内注射条件培养基，另一侧接受针刺和皮内注射生理盐水。该治疗分三个疗程进行，间隔三周。在第一次干预之前和最后一次治疗后三个月对患者进行评估。干预完成三个月后，使用生物识别标准评估患者的病变，医师评估，和病人的自我评估。
结果：结果表明，使用微针治疗的患者的真皮和完全厚度以及皮肤密度有了显着改善。在接受针刺和条件培养基组合的患者中，所有皮肤超声参数均显着改善。当比较两组时，联合治疗组的医师和患者满意度明显更高.然而,这些组之间生物识别指数改善的比较并不显著。
结论：人骨髓间充质干细胞与微针结合可被认为是妊娠纹的一种新的有效选择。
