PDF(Pubmed)
Abstract：
BACKGROUND: Most genetic skeletal disorders (GSD) were complex, disabling and life-threatening without effective diagnostic and treatment methods. However, its impacts on health system have not been well studied. The study aimed to systematically evaluate the health-care utilization and economic burden in GSD patients.
METHODS: The patients were derived from 2018 Nationwide Inpatient Sample and Nationwide Readmissions Database. GSD patients were extracted based on International Classification of Diseases-10th revision codes.
RESULTS: A total of 25,945 (0.12%) records regarding GSD were extracted from all 21,400,282 records in NIS database. GSD patients were likely to have significantly longer length of stay (6.50 ± 0.08 vs. 4.63 ± 0.002, P < 0.001), higher total charges ($85,180.97 ± 1,239.47 vs. $49,884.26 ± 20.99, P < 0.001), suffering more procedure, diagnosis and transferring records in comparison to patients with common conditions. GSD patients had a significantly higher 30-day all-cause readmission rate based on Nationwide Readmissions Database.
CONCLUSIONS: The heavy health-care utilization and economic burden emphasized the urgency for policy leaders, scientific and pharmaceutical researchers, health care providers and employers to identify innovative ways and take effective measurements immediately, and eventually to help improve the care, management, and treatment of these devastating diseases.
METHODS: The patients were derived from 2018 Nationwide Inpatient Sample and Nationwide Readmissions Database. GSD patients were extracted based on International Classification of Diseases-10th revision codes.
RESULTS: A total of 25,945 (0.12%) records regarding GSD were extracted from all 21,400,282 records in NIS database. GSD patients were likely to have significantly longer length of stay (6.50 ± 0.08 vs. 4.63 ± 0.002, P < 0.001), higher total charges ($85,180.97 ± 1,239.47 vs. $49,884.26 ± 20.99, P < 0.001), suffering more procedure, diagnosis and transferring records in comparison to patients with common conditions. GSD patients had a significantly higher 30-day all-cause readmission rate based on Nationwide Readmissions Database.
CONCLUSIONS: The heavy health-care utilization and economic burden emphasized the urgency for policy leaders, scientific and pharmaceutical researchers, health care providers and employers to identify innovative ways and take effective measurements immediately, and eventually to help improve the care, management, and treatment of these devastating diseases.
摘要：
背景：大多数遗传性骨骼疾病（GSD）是复杂的，如果没有有效的诊断和治疗方法，就会致残和危及生命。然而,它对卫生系统的影响还没有得到很好的研究。该研究旨在系统评估GSD患者的医疗保健利用和经济负担。
方法：患者来自2018年全国住院患者样本和全国再入院数据库。根据国际疾病分类第10次修订代码提取GSD患者。
结果：从NIS数据库中的所有21,400,282条记录中提取了25,945条（0.12％）关于GSD的记录。GSD患者可能有明显更长的住院时间（6.50±0.08vs.4.63±0.002,P<0.001),更高的总费用（85,180.97±1,239.47美元与$49,884.26±20.99，P<0.001），遭受更多的程序，与普通患者相比，诊断和转移记录。根据全国再入院数据库，GSD患者30天全因再入院率明显较高。
结论：沉重的医疗保健利用和经济负担强调了政策领导者的紧迫性，科学和制药研究人员，卫生保健提供者和雇主确定创新的方法，并立即采取有效的措施，最终帮助改善护理，管理,以及这些毁灭性疾病的治疗。
方法：患者来自2018年全国住院患者样本和全国再入院数据库。根据国际疾病分类第10次修订代码提取GSD患者。
结果：从NIS数据库中的所有21,400,282条记录中提取了25,945条（0.12％）关于GSD的记录。GSD患者可能有明显更长的住院时间（6.50±0.08vs.4.63±0.002,P<0.001),更高的总费用（85,180.97±1,239.47美元与$49,884.26±20.99，P<0.001），遭受更多的程序，与普通患者相比，诊断和转移记录。根据全国再入院数据库，GSD患者30天全因再入院率明显较高。
结论：沉重的医疗保健利用和经济负担强调了政策领导者的紧迫性，科学和制药研究人员，卫生保健提供者和雇主确定创新的方法，并立即采取有效的措施，最终帮助改善护理，管理,以及这些毁灭性疾病的治疗。
