PDF(Pubmed)
Abstract：
Lung cancer is a complicated and challenging disease and is one of the most common causes of cancer-related mortality worldwide. Within the lung microenvironment, specific cytokines, including the B cell activation factor (BAFF) and the A proliferation-inducing ligand (APRIL), are produce by various cells, notably airway epithelial cells, in response allergic inflammation or pulmonary infection. These cytokines play a critical role in maintaining local immune responses and fostering the survival of immune cells. The BAFF and APRIL system have been connected in a range of malignancies and have shown their potential in inducing drug resistance and promoting cancer progression. This review highlights recent studies on the involvement of BAFF and APRIL in various cancers, focusing mainly on their role in lung cancer, and discusses the possibility of these molecules in contributing to drug resistance and cancer progression following pulmonary infection. We suggest consideration the targeting BAFF and APRIL or their respective receptors as promising novel therapies for effective treatment of lung cancer, especially post pulmonary infection. However, it remains important to conduct further investigations to fully elucidate the precise mechanisms underlying how the BAFF and APRIL systems enhance cancer survival and drug resistance subsequent pulmonary infections.
摘要：
肺癌是一种复杂且具有挑战性的疾病，是全球癌症相关死亡的最常见原因之一。在肺微环境中，特异性细胞因子，包括B细胞活化因子（BAFF）和A增殖诱导配体（APRIL），是由各种细胞产生的，尤其是气道上皮细胞，在反应过敏性炎症或肺部感染。这些细胞因子在维持局部免疫应答和促进免疫细胞存活中起关键作用。BAFF和APRIL系统已在一系列恶性肿瘤中联系在一起，并显示出它们在诱导耐药性和促进癌症进展方面的潜力。这篇综述强调了最近关于BAFF和APRIL在各种癌症中的参与的研究。主要关注它们在肺癌中的作用，并讨论了这些分子在肺部感染后导致耐药性和癌症进展的可能性。我们建议考虑靶向BAFF和APRIL或它们各自的受体作为有效治疗肺癌的有希望的新疗法。尤其是肺部感染后.然而,开展进一步研究以充分阐明BAFF和APRIL系统如何提高癌症生存率和肺部感染后的耐药性的确切机制仍然很重要.
